EFFECTS OF INTRACORONARY INJECTION OF ACETYLCHOLINE ON CORONARY ARTERIAL DIAMETER
EFFECTS OF INTRACORONARY INJECTION OF ACETYLCHOLINE ON CORONARY ARTERIAL DIAMETER
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DOI：
10.1016/0002-9149(86)90743-5
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发表时间：
1986-04-15
影响因子：
2.8
通讯作者：
KIMURA, T
中科院分区：
文献类型：
--
作者：
HORIO, Y;YASUE, H;KIMURA, T
对30例冠状动脉造影正常或基本正常的成人患者（男13例，女17例）进行冠状动脉造影，观察冠状动脉内注射乙酰胆碱对冠状动脉直径的影响。排除心绞痛、心肌梗死等严重心脏病患者。在将30至100 μ g乙酰胆碱注射到左冠状动脉中后2分钟，左主干、左前降支近端、中段、远端、左旋支近端、中段、远端直径缩小25%以上者分别为1例（4%）、5例（20%）、3例（12%）、分别为9例（36%）、6例（24%）、8例（32%）和3例（12%）。在将30至50 μ g乙酰胆碱注射到右冠状动脉中后，20名患者中的5名（25%）、7名（35%）和10名（50%）分别发生了右冠状动脉近端、中部和远端的显著弥漫性狭窄。但少数患者左主干、左前降支、左回旋支和右冠状动脉出现明显的弥漫性扩张（直径增加25%以上）。这些结果表明，乙酰胆碱诱导冠状动脉血管收缩在一个显着的数字和冠状动脉血管舒张在少数成年人，和冠状动脉的反应乙酰胆碱沿着冠状动脉的过程。
The effects of intracoronary injection of acetylcholine on coronary arterial diameter was examined by coronary arteriography in 30 adult patients (13 men, 17 women), aged 23 to 67 years (mean 51), with normal or almost normal coronary arteriographic findings. Patients with angina pectoris, myocardial infarction and other severe cardiac diseases were excluded. Two minutes after injection of 30 to 100 .mu.g of acetylcholine into the left coronary artery, significant diffuse narrowing (more than 25% reduction in diameter) of the left main trunk, the proximal, mid- and distal left anterior descending artery, and the proximal, mid- and distal left circumflex artery occurred in 1 (4%), 5 (20%), 3 (12%), 9 (36%), 6 (24%), 8 (32%) and 3 (12%) of 25 patients, respectively. After injection of 30 to 50 .mu.g of acetylcholine into the right coronary artery, significant diffuse narrowing of the proximal, mid- and distal right coronary artery occcured in 5 (25%), 7 (35%) and 10 (50%) of 20 patients, respectively. However, significant diffuse dilatation (more than 25% increment in diameter) appeared in the left main trunk, left anterior descending, left circumflex and right coronary arteries in a few patients. These results indicate that acetylcholine induces coronary vasoconstriction in a significant number and coronary vasodilatation in a small number of adult humans, and that response of the coronary artery to acetylcholine varies along the course of the coronary artery.