A potential virulence gene, hylEfm, predominates in Enterococcus faecium of clinical origin
A potential virulence gene, hylEfm, predominates in Enterococcus faecium of clinical origin
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DOI：
10.1086/367711
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发表时间：
2003-02-01
影响因子：
6.4
通讯作者：
Murray, BE
中科院分区：
文献类型：
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作者：
Rice, LB;Carias, L;Murray, BE
已在屎肠球菌的非粪便分离株中鉴定出与先前描述的透明质酸酶基因同源的开放阅读框 (hyl(Efm))。对不同来源的屎肠球菌分离株 (n = p) 进行了筛选，以确定是否存在 577 hyl(Efm) 和 esp(Efm)，这是与流行性屎肠球菌菌株相关的假定毒力基因。 esp(Efm) 的存在量大约是 hyl(Efm) 的两倍，但两者主要发现于美国住院患者的非粪便培养物中的耐万古霉素屎肠球菌分离株中。这些数据表明，特定的屎肠球菌菌株可能富含决定子，使它们更有可能引起临床感染。这些菌株流行率的差异可能有助于解释不同大陆的多重耐药屎肠球菌的临床重要性的差异。
An open reading frame (hyl(Efm)) with homologies to previously described hyaluronidase genes has been identified in nonstool isolates of Enterococcus faecium. E. faecium isolates (n = p) from diverse sources were screened for the presence of 577 hyl(Efm) and esp(Efm), a putative virulence gene associated with epidemic E. faecium strains. The presence of esp(Efm) was roughly twice that of hyl(Efm), but both were found primarily in vancomycin-resistant E. faecium isolates in nonstool cultures obtained from patients hospitalized in the United States. These data suggest that specific E. faecium strains may be enriched in determinants that make them more likely to cause clinical infections. Differences in the prevalence of these strains may help explain variations in the clinical importance of multi-resistant E. faecium across different continents.