Newborn screening for autism: in search of candidate biomarkers.
Newborn screening for autism: in search of candidate biomarkers.
复制标题
DOI：
10.2217/bmm.12.108
复制
发表时间：
2013-04
影响因子：
2.2
通讯作者：
Pass KA
中科院分区：
文献类型：
--
作者：
Mizejewski GJ;Lindau-Shepard B;Pass KA
自闭症谱系障碍（ASD）是一种广泛的神经发育障碍，其特征是社会互动，语言，沟通和兴趣范围的障碍。自闭症通常在3-5岁的儿童中使用行为特征进行诊断;因此，出生后不久的诊断将有利于早期开始治疗。这项回顾性研究旨在通过免疫测定中的血斑标本来识别有ASD风险的新生儿。本研究使用了15-36个月大时已诊断为ASD的儿童的冷冻样本。新生儿标本和对照组在包括90种血清生物标志物的多重系统中通过免疫测定进行分析，并进行病理学分析。发现与ASD相关的三组五种生物标志物与对照组不同。然后讨论了15种候选生物标志物与ASD的相关性。这项研究确定了一个统计学选择的15个生物标志物的小组成功地区分推定的新生儿从未受影响的控制ASD的风险。
Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3–5 years of age using behavioral characteristics; thus, diagnosis shortly after birth would be beneficial for early initiation of treatment. This retrospective study sought to identify newborns at risk for ASD utilizing bloodspot specimens in an immunoassay. The present study utilized stored frozen specimens from ASD children already diagnosed at 15–36 months of age. The newborn specimens and controls were analyzed by immunoassay in a multiplex system that included 90 serum biomarkers and subjected to statisical analysis. Three sets of five biomarkers associated with ASD were found that differed from control groups. The 15 candidate biomarkers were then discussed regarding their association with ASD. This study determined that a statistically selected panel of 15 biomarkers successfully discriminated presumptive newborns at risk for ASD from those of nonaffected controls.