Effect of static pressure on acoustic transmittance of Albunex(R) microbubble suspensions
Effect of static pressure on acoustic transmittance of Albunex(R) microbubble suspensions
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DOI：
10.1121/1.415428
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发表时间：
1996-04-01
影响因子：
2.4
通讯作者：
Meltzer, RS
中科院分区：
文献类型：
--
作者：
Brayman, AA;Azadniv, M;Meltzer, RS
Albunex(R)(ALX)是一种白蛋白稳定的微泡回声造影剂，它对与心脏产生的压力类似的压力敏感。被检验的假设是ALX悬浮液的透声率随着静水压力的增加而增加(P-S)。测试涉及一种类似于分光光度计的声学设置。微泡悬浮液的透声系数强烈依赖于P-S。在常压下，1 MHz的透过率基本为零，在P-S为80、120和400 mm Hg时，透过率分别增加到接近50%、接近63%和接近100%。在实验测量期间，用于询问样品的超声脉冲对保持在环境压力下的悬浮液的声透过率没有可测量的影响。数据表明，许多微泡在P-S被破坏，与心脏产生的微泡相当。(C)1996年美国声学学会。
Albunex(R) (ALX), an albumin-stabilized microbubble echo contrast agent, is sensitive to pressures similar to those produced by the heart. The tested hypothesis was that the acoustic transmittance of ALX suspensions will increase with increasing hydrostatic pressure (P-s). The test involved an acoustic setup analogous;to a spectrophotometer. The acoustic transmittance of microbubble suspensions was strongly P-s dependent. Transmittance at 1 MHz was essentially zero at ambient pressure, increasing to similar to 50%, similar to 63%, and nearly 100% at P-s of 80, 120, and 400 mm Hg, respectively. The ultrasound pulses used to interrogate samples were without measurable effect on the acoustic transmittance of suspensions maintained at ambient pressure during experimental measurements. The data indicate that many of the microbubbles are destroyed at P-s comparable to those produced by the heart. (C) 1996 Acoustical Society of America.