Human transient receptor potential (TRP) channels expression profiling in carcinogenesis
Human transient receptor potential (TRP) channels expression profiling in carcinogenesis
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DOI：
10.1387/ijdb.150232dg
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发表时间：
2015-01-01
影响因子：
0.7
通讯作者：
Gkika, Dimitra
中科院分区：
文献类型：
--
作者：
Bernardini, Michela;Pla, Alessandra Fiorio;Gkika, Dimitra
尽管过去三十年对瞬时受体电位（TRP）阳离子通道进行了深入研究，但还没有关于这些通道参与生理病理学和致癌作用的精确和完整的分析。TRP通道活性对于癌发生的所有基本标志如增殖、凋亡、迁移和血管生成是至关重要的，这就是为什么这些通道不仅被提出作为临床标志物，而且被提出作为抗癌治疗的有希望的靶点的原因。然而，在大多数研究中，每个通道都被认为是一个单独的分子实体，并独立于其他TRP进行研究，而有效使用这些靶点需要癌发生特定阶段的完整“转运组”。这篇评论的重点是在文献中发现的部分TRP表达谱和手段，通过它可以实现一个完整的TRP签名。
Despite the intensive research of the last three decades into Transient Receptor Potential (TRP) cation channels, no precise and complete profiling of these channels is yet available regarding their involvement in physiopathology and carcinogenesis in particular. TRP channel activity is crucial for all the essential hallmarks of carcinogenesis such as proliferation, apoptosis, migration and angiogenesis, which is the reason why these channels have been proposed not only as clinical markers, but also as promising targets for anti-cancer therapy. However, in the majority of studies, each channel has been considered as a separate molecular entity and studied independently from the other TRPs, while a complete "transportome" of the specific stages of carcinogenesis is required for the effective use of these targets. This review focuses on the partial TRP expression profiles found in the literature and the means by which a full TRP signature could be achieved.