REPRODUCTIVE EFFECTS OF OLFACTORY BULBECTOMY IN THE SYRIAN-HAMSTER
REPRODUCTIVE EFFECTS OF OLFACTORY BULBECTOMY IN THE SYRIAN-HAMSTER
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DOI：
10.1095/biolreprod35.5.1202
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发表时间：
1986-12-01
影响因子：
3.6
通讯作者：
MACRIDES, F
中科院分区：
文献类型：
--
作者：
CLANCY, AN;GOLDMAN, BD;MACRIDES, F
嗅球切除术对循环促性腺激素，催乳素和睾酮水平的影响，并对睾丸和垂体的反应，缩短白天在叙利亚仓鼠进行了研究。维持在14 L：10 D循环的成年动物通过抽吸进行假手术或持续双侧根治性嗅球切除术，以去除主嗅球和副嗅球以及前嗅核的邻近区域。然后将它们保持在长光周期或以10 L：14 D循环饲养。在5个月的时间内，每周测量睾丸长度。假手术对照组表现出睾丸退化的正常模式，并最终在短光周期内复发。睾丸球切除动物的睾丸退化显著减少。这些动物中的许多动物未显示退化;其他动物表现出退化程度降低和/或退化持续时间缩短。在长时间维持的球切除雄性中，血清促卵泡激素（FSH）水平显著升高。它们的血清促黄体生成素（LH）、催乳素和睾酮水平保持在长光周期假处理的范围内。在短短几天内，球切除动物表现出正常的，循环催乳素水平明显下降。血清FSH和LH水平也显示出大幅下降，但FSH水平没有降低到控制范围以下，在长的日子里，LH水平的下降是不是为控制在短的日子里那么大。因此，在球切除动物中，睾丸对短日照反应的抑制可能不是由于对光周期本身的影响，而是由于对促性腺激素分泌的一般刺激和/或促进作用，以及短光照周期导致促性腺激素水平持续降低至低于能够维持睾丸功能的水平。
The effects of olfactory bulbectomy on circulating gonadotropin, prolactin and testosterone levels and on the testicular and pituitary responses to shortening of day length were studied in Syrian hamsters. Adult animals maintained on a 14L:10D cycle were sham-operated or sustained bilateral radical olfactory bulbectomies by aspiration to remove the main and accessory olfactory bulbs and the adjacent regions of the anterior olfactory nucleus. They were then maintained either on the long photoperiod or housed on a 10L:14D cycle. Testicular length was measured at weekly intervals over a 5-mo period. Sham-operated controls exhibited the normal pattern of testicular regression and eventual recrudescence on the short photoperiod. Testicular regression was significantly reduced in bulbectomized animals. Many of these animals showed no regression; others exhibited a reduced degree and/or shortened duration of regression. Serum levels of follicle-stimulating hormone (FSH) were substantially elevated in bulbectomized males maintained in long days. Their serum levels of luteinizing hormone (LH), prolactin and testosterone remained within the range for shams on long photoperiod. In short days, the bulbectomized animals showed the normal, pronounced decline in circulating prolactin levels. Serum FSH and LH levels also showed substantial declines, but the FSH levels were not reduced below the range for controls in long days, and the decline in LH levels was not as great as that for controls in short days. The suppression of the testicular response to short days in bulbectomized animals thus may not be due to effects on photoperiodism per se, but rather to general stimulatory and/or facilitatory effects on gonadotropin secretion, and a consequent failure of short photoperiod to reduce gonadotropin levels consistently below those capable of maintaining testis function.