IMMUNOPEROXIDASE STUDY OF THE SECRETORY IMMUNOGLOBULIN SYSTEM IN COLONIC NEOPLASIA
IMMUNOPEROXIDASE STUDY OF THE SECRETORY IMMUNOGLOBULIN SYSTEM IN COLONIC NEOPLASIA
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DOI：
10.1136/jcp.35.1.14
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发表时间：
1982-01-01
影响因子：
3.4
通讯作者：
ISAACSON, P
中科院分区：
文献类型：
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作者：
ISAACSON, P
通过对癌、腺瘤和溃疡性结肠炎病例的福尔马林固定、石蜡包埋切片进行常规染色，检查分泌成分 (SC)、IgA 和 J 链，检查[人]结肠中的分泌性免疫球蛋白系统与结直肠癌和发育不良的关系。在癌中，SC 合成和分化之间存在密切关系，并且在腺瘤中 SC 合成和不典型增生程度之间也存在明显的类似关系。从形态学和功能（SC合成）角度来看，腺瘤的不典型增生程度与癌的分化程度相似，表明向肿瘤进展的基本转变可能发生在腺瘤水平，并且侵袭性恶性肿瘤可能由不同严重程度的不典型增生粘膜引起。溃疡性结肠炎 (UC) 中活跃再生的粘膜显示出 SC 的强烈染色，而癌前不典型增生病灶的染色则明显减少或不存在，其中，除了一种例外，染色明显减少或不存在，这表明 SC 染色可用于识别 UC 中癌前不典型增生的病灶。在没有像 UC 那样的严重慢性炎症的情况下，含有 IgA 的浆细胞数量与肿瘤粘膜的 SC 染色密切相关，表明 SC 可能在 IgA 淋巴细胞归巢到结肠固有层的机制中发挥重要作用。
The relation of the secretory immunoglobulin system in the [human] colon to colorectal cancer and dysplasia was examined by staining routine formalin-fixed, paraffin-embedded sections from cases of carcinoma, adenoma and ulcerative colitis for secretory component (SC), IgA and J chain. In carcinomas there was a close relation between SC synthesis and differentiation and a similar relation was apparent between SC synthesis and degrees of dysplasia in adenomas. In morphological and functional (SC synthesis) terms, degrees of dysplasia in adenomas resembled degrees of differentiation in carcinomas suggesting that the essential switch in the progression towards neoplasia may occur at the level of the adenoma and that invasive malignancy can arise from dysplastic mucosa of varying severity. Actively regenerating mucosa in ulcerative colitis (UC) showed intense staining for SC as opposed to foci of precancerous dysplasia where, with one exception, staining was markedly reduced or absent, suggesting staining for SC could be useful in identifying foci of precancerous dysplasia in UC. In the absence of severe chronic inflammation as in UC, the number of IgA-containing plasma cells was closely related to SC staining of neoplastic mucosa suggesting that SC may be important in the mechanism by which IgA lymphocytes home to the lamina propria of the colon.