Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity
Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity
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DOI：
10.1016/j.neuroimage.2021.118094
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发表时间：
2021-05-13
期刊：
影响因子：
5.7
通讯作者：
Paulk, Angelique C.
中科院分区：
文献类型：
--
作者：
Crocker, Britni;Ostrowski, Lauren;Paulk, Angelique C.
测量人脑中的连通性涉及使用非侵入性（fMRI，EEG）和侵入性（颅内EEG或iEEG）记录模式的无数方法，包括使用外部探测刺激，如直接电刺激。为了研究不同的连接性测量如何相互关联，我们将静息状态条件下的“被动”连接性测量与单脉冲电刺激（SPES）连接性的更“主动”探测测量进行了比较。我们测量了在大脑104个部位中的53个部位（包括皮质和皮质下区域）由SPES诱导的皮质-皮质诱发电位（CCEP）的网络参与和扩散，这些部位是难治性癫痫患者（N = 11），这些患者接受颅内记录作为其临床护理的一部分，用于识别癫痫发作区域。我们将CCEP网络与每位患者静息状态下的功能性、有效性和结构性连接措施进行了比较。功能和有效的连接措施，包括相关性或格兰杰因果关系的措施，适用于立体脑电图（sEEG）记录。结构连通性来源于颅内电极植入和监测前采集的弥散张量成像（DTI）（N = 8）。CCEP网络与静息态电压相关网络在靠近刺激位置的通道中最为相似。相反，远端CCEP网络与DTI网络最相似。其他连接措施与CCEP网络不太相似。这些结果表明，不同的连接措施，包括那些来自主动刺激为基础的探测，测量不同的，互补的方面，在大脑中的区域相互关系。
Measuring connectivity in the human brain involves innumerable approaches using both noninvasive (fMRI, EEG) and invasive (intracranial EEG or iEEG) recording modalities, including the use of external probing stimuli, such as direct electrical stimulation. To examine how different measures of connectivity correlate with one another, we compared 'passive' measures of connectivity during resting state conditions to the more 'active' probing measures of connectivity with single pulse electrical stimulation (SPES). We measured the network engagement and spread of the cortico-cortico evoked potential (CCEP) induced by SPES at 53 out of 104 total sites across the brain, including cortical and subcortical regions, in patients with intractable epilepsy (N = 11) who were undergoing intracranial recordings as a part of their clinical care for identifying seizure onset zones. We compared the CCEP network to functional, effective, and structural measures of connectivity during a resting state in each patient. Functional and effective connectivity measures included correlation or Granger causality measures applied to stereoEEG (sEEGs) recordings. Structural connectivity was derived from diffusion tensor imaging (DTI) acquired before intracranial electrode implant and monitoring (N = 8). The CCEP network was most similar to the resting state voltage correlation network in channels near to the stimulation location. In contrast, the distant CCEP network was most similar to the DTI network. Other connectivity measures were not as similar to the CCEP network. These results demonstrate that different connectivity measures, including those derived from active stimulation-based probing, measure different, complementary aspects of regional interrelationships in the brain.