An In Vivo Verification of the Intravoxel Incoherent Motion Effect in Diffusion-Weighted Imaging of the Abdomen
An In Vivo Verification of the Intravoxel Incoherent Motion Effect in Diffusion-Weighted Imaging of the Abdomen
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DOI：
10.1002/mrm.22565
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发表时间：
2010-12-01
影响因子：
3.3
通讯作者：
Schad, Lothar R.
中科院分区：
文献类型：
--
作者：
Lemke, Andreas;Laun, Frederik B.;Schad, Lothar R.
为了研究血管对测量的表观扩散系数的贡献并验证下体素不相干运动理论，在健康胰腺中测量了作为 b 值函数的信号，在抑制和不抑制血管成分的情况下以及在不同的回波时间（TE = 50、70 和 100 毫秒）下。使用原始的 Infra Voxel 不相干运动方程和包含松弛效应的该方程的修改版本，从测量的 DW 数据中提取灌注分数 f 和扩散系数 D。首先，血液抑制的胰腺组织中的灌注分数f显着降低（P = 0.03），而扩散系数D并没有随着抑制而改变（P = 0.43）。其次，灌注分数 f 随着回波时间的增加而显着增加 (P = 0.0025)，而弛豫时间补偿灌注分数 f' 显示对 TE 没有显着依赖性 (P = 0.31)。这些结果验证了血管对低 b 值下的扩散加权成像测量的贡献，并支持体素内不相干运动理论。 Magn Reson Med 64:1580-1585, 2010。(C) 2010 Wiley-Liss, Inc.
To investigate the vascular contribution to the measured apparent diffusion coefficient and to validate the Infra Voxel Incoherent Motion theory, the signal as a function of the b-value was measured in the healthy pancreas with and without suppression of the vascular component and under varying echo times (TE = 50, 70, and 100 msec). The perfusion fraction f and the diffusion coefficient D were extracted from the measured DW-data using the original Infra Voxel Incoherent Motion-equation and a modified version of this equation incorporating relaxation effects. First, the perfusion fraction f in the blood suppressed pancreatic tissue decreased significantly (P = 0.03), whereas the diffusion coefficient D did not change with suppression (P = 0.43). Second, the perfusion fraction f increased significantly with increasing echo time (P = 0.0025), whereas the relaxation time compensated perfusion fraction f' showed no significant dependence on TE (P = 0.31). These results verify a vascular contribution to the diffusion weighted imaging measurement at low b values and support the Intra Voxel Incoherent Motiontheory. Magn Reson Med 64:1580-1585, 2010. (C) 2010 Wiley-Liss, Inc.