Plasma monocyte chemoattractant protein-1 as risk marker in type 2 diabetes mellitus and coronary artery disease in North Indians
Plasma monocyte chemoattractant protein-1 as risk marker in type 2 diabetes mellitus and coronary artery disease in North Indians
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DOI：
10.1177/1479164109346364
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发表时间：
2009-10-01
影响因子：
2.4
通讯作者：
Vasudha, Sambyal
中科院分区：
文献类型：
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作者：
Harsimran, Kaur;Singh, Arora Ajinder Pal;Vasudha, Sambyal
趋化因子单核细胞趋化蛋白-1(MCP-1)与慢性炎症、胰岛素抵抗和动脉粥样硬化有关。本研究旨在探讨2型糖尿病合并冠心病(CAD)患者血浆单核细胞趋化蛋白-1(MCP-1)水平与疾病病理的关系。空腹采静脉血162例，分为4组：2型糖尿病合并冠心病组(n=41)、2型糖尿病非冠心病组(n=50)、无糖尿病病史冠心病组(n=41)和健康对照组(n=30)。使用标准程序测量体重指数、体脂百分比、腰臀比、血压和体力活动等冠心病危险因素。用双抗体夹心酶联免疫吸附试验测定血浆单核细胞趋化蛋白-1水平。在MCP-1水平、体脂百分比、体重指数、腰臀比、收缩压和舒张压方面，各组之间存在显著差异。单核细胞趋化蛋白-1浓度与糖尿病病程显著相关(p
The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in chronic inflammation, insulin resistance and atherosclerosis. The present study was designed to explore the relation of plasma levels of MCP-1 to disease pathology in type 2 diabetes and coronary artery disease (CAD) patients. Fasting plasma venous samples were taken from 162 subjects divided into four groups: Patients with type 2 diabetes mellitus and CAD (n=41), type 2 diabetes patients without CAD (n=50), CAD patients with no history of diabetes (n=41) and healthy controls (n=30). Coronary risk factors such as body mass index, percentage body fat, waist/hip ratio, blood pressure and physical activity were measured using standard procedures. Plasma MCP-1 was quantitatively estimated by sandwich enzyme-linked immunoabsorbent assay (ELISA). Significant differences were observed for MCP-1 levels, percent body fat, body mass index, waist/hip ratio, systolic and diastolic blood pressure amongst the groups. MCP-1 concentration was significantly correlated with diabetes duration (p