Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2alpha on pulmonary mechanics in the guinea pig.
Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2alpha on pulmonary mechanics in the guinea pig.
复制标题
静脉注射过敏反应慢反应物质、组胺、缓激肽和前列腺素 F2α 对豚鼠肺力学的影响。
DOI：
10.1172/jci107719
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
Frank Austen
中科院分区：
文献类型：
--
作者：
Jefrey M. Drazen;K.;Frank Austen
观察静脉注射过敏性慢反应物质(SRS-A)、组胺、缓激肽和前列腺素F(2α)(PGF(2α))纯化制剂对豚鼠呼吸力学的影响。几何剂量递增的SRS-A导致平均肺顺应性逐渐降低，平均肺阻力仅有轻微增加。具有明显最大效果的剂量。3,000 U/kg，导致顺应性比控制值降低49+/-7%，阻力比对照增加24+/-8%。静脉注射几何量递增的组胺、缓激肽和前列腺素F(2pha)也会导致顺应性降低；但在每种情况下，这都伴随着呼吸阻力的显著增加。静脉注射组胺、缓激肽或前列腺素F(2α)引起的顺应性下降约50%，同时伴随着60%-140%的抵抗力增加。因此，静脉注射SRS-A对肺力学的改变比任何其他被测试的药物都更具外围效应。
The effects of intravenous administration of a purified preparation of slow-reacting substance of anaphylaxis (SRS-A), histamine, bradykinin, and prostaglandin F(2alpha) (PGF(2alpha)) on the mechanics of respiration were assessed in the unanesthetized guinea pig. Geometrically increasing doses of SRS-A resulted in graded decreases in average pulmonary compliance, with only modest increases in average pulmonary resistance. A dose with apparent maximal effects. 3,000 U/kg, resulted in a decrease of 49+/-7% of compliance below control values, with an increase in resistance of 24+/-8% above control. Intravenous administration of geometrically increasing amounts of histamine, bradykinin, and prostaglandin F(2alpha) also resulted in decreased compliance; but in each case this was accompanied by a marked increase in respiratory resistance. A decrease of compliance of approximately 50%, induced by intravenous histamine, bradykinin, or PGF(2alpha), was accompanied by an increase of 60-140% in resistance. Thus, intravenously administered SRS-A alters pulmonary mechanics with a more peripheral effect than any of the other agents tested.