Skin cancer in people with multiple sclerosis: a record linkage study
Skin cancer in people with multiple sclerosis: a record linkage study
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DOI：
10.1136/jech.58.2.142
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发表时间：
2004-02-01
影响因子：
6.3
通讯作者：
Acheson, ED
中科院分区：
文献类型：
--
作者：
Goldacre, MJ;Seagroatt, V;Acheson, ED
目的：多发性硬化症（MS）的患病率随纬度的变化而变化：在两个半球，它随着距离赤道的距离而增加。为了寻找太阳辐射是否是多发性硬化症的保护因素的证据，本研究调查了作为太阳辐射指标的皮肤癌在多发性硬化症患者中是否比其他人更少见。设计：分析关联医院记录和死亡证明的数据库。地点：英国国家卫生服务的牛津地区。研究对象：包括数据库中所有患有多发性硬化症的人，以及患有其他疾病的人的比较队列。结果：MS患者中皮肤癌的发生率明显低于主要对照队列（发病率比0.49；95%可信区间0.24 ~ 0.91）。在多发性硬化症队列中没有普遍的癌症缺陷，在患有其他自身免疫性或神经系统疾病的人群中也没有皮肤癌缺陷。结论：本研究结果支持太阳辐射可能对多发性硬化症的发生有保护作用的假设。
Objective: The prevalence of multiple sclerosis (MS) varies with latitude: it increases with distance from the equator in both hemispheres. To seek evidence on whether solar radiation is a protective factor for MS, this study investigated whether skin cancer, as an indicator of solar radiation, is less common in people with MS than in others.Design: Analysis of a database of linked hospital records and death certificates.Setting: The Oxford Region of the National Health Service, England.Subjects: A cohort comprising all people in the database with MS, and comparison cohorts of people with other diseases.Results: Skin cancer was significantly less common in people with MS than in the main comparison cohort (rate ratio 0.49; 95% confidence interval 0.24 to 0.91). There was no general deficit of cancer in the MS cohort, and no deficit of skin cancer in cohorts of people with other autoimmune or neurological diseases.Conclusion: The findings support the hypothesis that solar radiation may have a protective influence on the development of MS.