Shuttling components of nuclear import machinery involved in nuclear translocation of steroid receptors exit nucleus via exportin-1/CRM-1 independent pathway
Shuttling components of nuclear import machinery involved in nuclear translocation of steroid receptors exit nucleus via exportin-1/CRM-1 independent pathway
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DOI：
10.1016/j.bbamcr.2004.03.003
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发表时间：
2004-05-03
影响因子：
5.1
通讯作者：
Tyagi, RK
中科院分区：
文献类型：
--
作者：
Kumar, S;Chaturvedi, NK;Tyagi, RK
核质转运过程是由可溶性转运因子介导的，这些转运因子不断在核质间室之间导航。我们对将货物运送到核的一般“核进口因素”的核出口的理解仍然是零碎的。利用绿色荧光蛋白标记的糖皮质激素受体（GR）和relA作为我们的工作模型，并明智地使用LMB，我们在活细胞中显示，所有的可溶性成分的核输入机制通过exportin 1/CRM 1独立的途径退出细胞核。(C)2004 Elsevier B. V.保留所有权利。
The nucleocytoplasmic transport processes are mediated by soluble transport factors constantly navigating between nuclear and cytoplasmic compartments. Our understanding about nuclear export of general 'nuclear import factors' that deliver the cargo to the nucleus is still fragmentary. Utilizing green fluorescent protein tagged glucocorticoid receptor (GR) and relA as our working model and with judicious use of LMB, we show in living cells that all the soluble components of the nuclear import machinery exit nucleus via exportin1/CRM1 independent pathway(s). (C) 2004 Elsevier B.V. All rights reserved.