Improved anatomic delineation of the antidepressant response to partial sleep deprivation in medial frontal cortex using perfusion-weighted functional MRI
Improved anatomic delineation of the antidepressant response to partial sleep deprivation in medial frontal cortex using perfusion-weighted functional MRI
复制标题
DOI：
10.1016/j.pscychresns.2005.12.008
复制
发表时间：
2006-04-30
影响因子：
2.3
通讯作者：
Gillin, J. Christian
中科院分区：
文献类型：
--
作者：
Clark, Camellia P.;Brown, Gregory G.;Gillin, J. Christian
本研究使用功能性磁共振成像（fMRI）来阐明与睡眠剥夺（SD）的抗抑郁作用相关的大脑活动部位。我们假设：1）抑郁反应者的基线腹侧前扣带回（AC）灌注将大于无反应者和对照者; 2）部分睡眠剥夺（PSD）后，腹侧AC灌注仅在反应者中显著降低。17名未服药的门诊抑郁症患者和8名对照组患者在基线和深夜PSD后1晚接受灌注加权fMRI和结构MRI检查。将Talairach变换的灰质掩模与基于Talairach守护进程的感兴趣区域（1101）模板合并。应答者的基线左腹侧AC（LVAC）灌注高于无应答者。在内侧额叶皮层没有差异。与无应答者和对照组相比，应答者的LVAC灌注从基线到PSD扫描下降，右背侧AC的灌注也是如此。在整个患者组中，从基线到PSD扫描的LVAC灌注降低与基线和PSD条件之间的改良17项汉密尔顿抑郁评定量表（HDRS 17）的降低直接相关。这些数据-首次使用fMRI-显示更大的解剖特异性比以前的研究结果，SD和抑郁症在连接减少大脑活动在这方面的临床改善。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
This study used functional magnetic resonance imaging (fMRI) to clarify the sites of brain activity associated with the antidepressant effects of sleep deprivation (SD). We hypothesized: 1) depressed responders' baseline ventral anterior cingulate (AC) perfusion will be greater than that of nonresponders and controls; 2) following partial sleep deprivation (PSD), ventral AC perfusion will significantly decrease in responders only. Seventeen unmedicated outpatients with current major depression and eight controls received perfusion-weighted fMRI and structural MRI at baseline and following I night of late-night PSD. Talairach-transformed gray matter masks were merged with Talairach Daemon-based region of interest (1101) templates. Baseline left ventral AC (LVAC) perfusion was greater in responders than nonresponders. There was no difference involving the medial frontal cortex. Responders' LVAC perfusion dropped from baseline to PSD scans compared with nonresponders and controls, as did perfusion in the right dorsal AC. In the patient group as a whole, decrease in LVAC perfusion from baseline to PSD scans correlated directly with the decrease in the modified 17-item Hamilton Depression Rating Scale (HDRS17) between baseline and PSD conditions. These data-the first using fMRI-show greater anatomic specificity than previous findings of SD and depression in linking decreased brain activity in this area with clinical improvement. (c) 2005 Elsevier Ireland Ltd. All rights reserved.