Immune System Dysfunction in the Elderly
Immune System Dysfunction in the Elderly
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DOI：
10.1590/0001-3765201720160487
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发表时间：
2017-03-01
期刊：
影响因子：
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通讯作者：
PALOMO, IVÁN
中科院分区：
文献类型：
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作者：
FUENTES, EDUARDO;FUENTES, MANUEL;PALOMO, IVÁN
人类衰老的特征是身体和生理虚弱，这会深刻影响免疫系统。在这种情况下，衰老与建立为免疫衰老的适应性和先天免疫的下降有关。免疫衰老是一个新的概念，反映了与年龄相关的先天性和适应性免疫功能的重组变化。因此，老年人通常存在慢性低水平炎症，较高的感染率和慢性疾病。对衰老过程中免疫系统变化的研究可能为评估免疫衰老治疗提供潜在有用的生物标志物。免疫系统是先天免疫和适应性免疫之间相互作用的结果，但衰老对这一功能的影响尚不清楚。在这篇文章中，免疫系统在衰老过程中的功能进行了探讨。
Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this function is unclear. In this article the function of the immune system during aging is explored.