Plasma carotenoids as biomarkers of intake of fruits and vegetables:: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Plasma carotenoids as biomarkers of intake of fruits and vegetables:: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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DOI：
10.1038/sj.ejcn.1602252
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发表时间：
2005-12-01
影响因子：
4.7
通讯作者：
Riboli, E
中科院分区：
文献类型：
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作者：
Al-Delaimy, WK;Ferrari, P;Riboli, E
目的：本研究的目的是评估欧洲9个不同国家的血浆类胡萝卜素水平(α-胡萝卜素、β-胡萝卜素、番茄红素、β-隐黄素、叶黄素、玉米黄质)与水果和蔬菜摄入量之间的关系，这些国家在1992-2000年间提供了血样、饮食和其他生活方式信息。结果：β-隐黄素与总水果(FQ r=0.52，24HDR r=0.39)、番茄红素与番茄及番茄制品(FQ r=0.38，24HDR r=0.25)、α-胡萝卜素(r=0.39)和总胡萝卜(r=0.38)的相关性最强。根据FQ测量的饮食，并根据体重指数(BMI)、年龄、性别、吸烟状况、酒精摄入量和能量摄入量调整可能的混杂因素，对个体血浆类胡萝卜素水平的最强预测因子是水果(R-Partial(2)=17.2%)和总胡萝卜(R-Partial(2)=13.4%)和根菜(R-Partial(2)=13.3%)和番茄红素(R-Partial(2)=13.8%)。对于24HDR，水果的R偏(2)最高(7.9%)。结论：在我们的多中心欧洲研究中，通过食物问卷测量的特定水果和蔬菜的摄入量可以很好地预测特定个体的血浆类胡萝卜素水平。在个别受试者水平上，水果、根茎蔬菜和胡萝卜以及番茄制品的FQ测量分别是血浆中β-隐黄素、α-胡萝卜素和番茄红素的良好预测因子。
Objective: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24- h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods.Design: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included.Results: beta-Cryptoxanthin was most strongly correlated with total fruits (FQ r = 0.52, 24HDR r = 0.39), lycopene with tomato and tomato products (FQ r = 0.38, 24HDR r = 0.25), and alpha-carotene with intake of root vegetables (r = 0.39) and of total carrots (r = 0.38) for FQ only. Based on diet measured by FQ and adjusting for possible confounding by body mass index (BMI), age, gender, smoking status, alcohol intake, and energy intake, the strongest predictors of individual plasma carotenoid levels were fruits (R-partial(2) = 17.2%) for beta-cryptoxanthin, total carrots (R-partial(2) = 13.4%) and root vegetables (R-partial(2) = 13.3%) for alpha-carotene, and tomato products (R-partial(2) = 13.8%) for lycopene. For 24HDR, the highest R-partial(2) was for fruits in relation to beta-cryptoxanthin (7.9%).Conclusions: Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in our multicentre European study. At individual subject levels, FQ measurements of fruits, root vegetables and carrots, and tomato products are, respectively, good predictors of beta-cryptoxanthin, alpha-carotene, and lycopene in plasma.