MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths.
MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths.
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DOI：
10.1016/j.neuroimage.2009.02.010
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发表时间：
2009-05-15
期刊：
影响因子：
5.7
通讯作者：
Fischl B
中科院分区：
文献类型：
--
作者：
Jovicich J;Czanner S;Han X;Salat D;van der Kouwe A;Quinn B;Pacheco J;Albert M;Killiany R;Blacker D;Maguire P;Rosas D;Makris N;Gollub R;Dale A;Dickerson BC;Fischl B
体内人脑体积的自动MRI衍生测量值提供了对正常和异常神经解剖学的新见解，但对测量可靠性知之甚少。在这里，我们评估了图像采集变量（扫描会话，MRI序列，扫描仪升级，供应商和现场强度），FreesUrfer分割预处理变量（图像平均，B1野外非均匀性校正）和分段分析变量（概率图像分割）的影响来自较大的人（n = 15，平均年龄69.5）和较年轻（n = 5，平均年龄34岁和36.5）的体积。在不同日期，在同一扫描仪上，海马，丘脑，尾状，梭子，梭子，外侧室内和总颅内体积测量值的变异性小于4.3％，年轻组的变异性小于2.3％。扫描仪内测量在整个扫描过程中非常可靠，受到多次收购，B1校正，采集序列（Mprage vs. Multi-Echo-Flash）的平均影响，大小的影响很小。分段地图集（mprage或多回声闪烁）。跨平台（西门子奏鸣曲与GE Signa）和野外强度（1.5T vs. 3t）的体积测量会导致体积差偏差，但具有可比的差异，与扫描仪内测量的差异相当，这意味着多站点研究可能不一定需要一个更大的样本以检测特定效果。这些结果表明，即使在升级后，T1加权结构图像的自动分割中得出的体积也是可靠的措施。但是，在平台和跨强度之间的数据组合引入了一种偏差，该偏差应在多站点研究的设计中考虑，例如临床药物试验。源自年轻组（扫描仪升级效果和B1不均匀性校正效应）的结果应视为初步，并且需要使用较大的数据集进行进一步验证。
Automated MRI-derived measurements of in-vivo human brain volumes provide novel insights into normal and abnormal neuroanatomy, but little is known about measurement reliability. Here we assess the impact of image acquisition variables (scan session, MRI sequence, scanner upgrade, vendor and field strengths), Freesurfer segmentation preprocessing variables (image averaging, B1 field inhomogeneity correction) and segmentation analysis variables (probabilistic atlas) on resultant image segmentation volumes from older (n=15, mean age 69.5) and younger (both n=5, mean ages 34 and 36.5) healthy subjects. The variability between hippocampal, thalamic, caudate, putamen, lateral ventricular and total intracranial volume measures across sessions on the same scanner on different days is less than 4.3% for the older group and less than 2.3% for the younger group. Within-scanner measurements are remarkably reliable across scan sessions, being minimally affected by averaging of multiple acquisitions, B1 correction, acquisition sequence (MPRAGE vs. multi-echo-FLASH), major scanner upgrades (Sonata-Avanto, Trio-TrioTIM), and segmentation atlas (MPRAGE or multi-echo-FLASH). Volume measurements across platforms (Siemens Sonata vs. GE Signa) and field strengths (1.5T vs. 3T) result in a volume difference bias but with a comparable variance as that measured within-scanner, implying that multi-site studies may not necessarily require a much larger sample to detect a specific effect. These results suggest that volumes derived from automated segmentation of T1-weighted structural images are reliable measures within the same scanner platform, even after upgrades; however, combining data across platform and across field-strength introduces a bias that should be considered in the design of multi-site studies, such as clinical drug trials. The results derived from the young groups (scanner upgrade effects and B1 inhomogeneity correction effects) should be considered as preliminary and in need for further validation with a larger dataset.
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DOI：
10.1602/neurorx.1.2.196
发表时间：
2004-04-01
期刊：
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Kantarci, Kejal;Jack, Clifford R Jr
通讯作者：
Jack, Clifford R Jr
影响因子：
2.4
作者：
Anderson, Valerie M.;Fernando, Kryshani T. M.;Fox, Nick C.
通讯作者：
Fox, Nick C.
影响因子：
5.7
作者：
Jovicich, J;Czanner, S;Dale, A
通讯作者：
Dale, A
影响因子：
9.9
作者：
Jack, CR;Shiung, MM;Petersen, RC
通讯作者：
Petersen, RC
影响因子：
5.7
作者：
Ashburner, J;Friston, KJ
通讯作者：
Friston, KJ