Cervical human papillomavirus infection in Mexican women with systemic lupus erythematosus or rheumatoid arthritis
Cervical human papillomavirus infection in Mexican women with systemic lupus erythematosus or rheumatoid arthritis
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DOI：
10.1177/0961203311425517
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发表时间：
2012-04-01
期刊：
影响因子：
2.6
通讯作者：
Gonzalez-Lopez, L.
中科院分区：
文献类型：
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作者：
Rojo-Contreras, W.;Olivas-Flores, E. M.;Gonzalez-Lopez, L.
宫颈人乳头瘤病毒（HPV+）感染与宫颈不典型增生的风险增加有关。虽然HPV+在系统性红斑狼疮（SLE）中的频率已经在一些种族中进行了调查，但其在西班牙裔女性中的患病率仍然未知。这项横断面研究评估了墨西哥SLE（n = 34）或类风湿性关节炎（RA）（n = 43）女性和健康对照组（n = 146）中宫颈HPV+的患病率。对这些妇女进行了关于性传播感染风险因素的访谈，并进行了宫颈细胞学分析。使用PCR鉴定HPV+病毒类型：在14.7%的SLE、27.9%的RA和30.8%的对照中观察到HPV+。高危型HPV在11.7%的SLE女性、27.9%的RA女性和26%的对照组中观察到。高危病毒58、35和18型在SLE中最常见。两名SLE患者有高度鳞状上皮内病变，一名患有宫颈癌。甲氨蝶呤的使用、泼尼松治疗时间较长和RA或SLE中HPV阳性之间存在相关性。因此，在患有SLE或RA的墨西哥女性中，宫颈HPV感染的患病率很高，医生必须警惕预防宫颈发育不良的发展。Lupus（2012）21，365-372.
Cervical human papillomavirus (HPV+) infection is associated with an increased risk of cervical dysplasia. Although the frequency of HPV+ in systemic lupus erythematosus (SLE) has been investigated in some races its prevalence in Hispanic women is still unknown. This cross-sectional study evaluated the prevalence of cervical HPV+ in Mexican women with SLE (n = 34) or rheumatoid arthritis (RA) (n = 43) and in healthy controls (n = 146). These women were interviewed about risk factors for sexually transmitted infections and cervical cytology analysis was performed. HPV+ viral types were identified using PCR: HPV+ was observed in 14.7% of SLE, 27.9% of RA and 30.8% of controls. High-risk HPV types were observed in 11.7% of women with SLE, 27.9% of women with RA, and in 26% of the controls. High-risk viral types 58, 35 and 18 were the most frequently identified in SLE. Two women with SLE had a high-grade squamous intraepithelial lesion and one had cervical cancer. An association was observed between methotrexate utilization, longer duration of therapy with prednisone, and HPV+ in RA or SLE. Thus, there is a high prevalence of cervical HPV infection in Mexican women with SLE or RA, and physicians must be vigilant in preventing the development of cervical dysplasia. Lupus (2012) 21, 365-372.