The role of thiocyanate in the etiology of goiter in an industrial metropolitan area
The role of thiocyanate in the etiology of goiter in an industrial metropolitan area
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DOI：
10.1530/eje.1.02076
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发表时间：
2006-02-01
影响因子：
5.8
通讯作者：
Paschke, R
中科院分区：
文献类型：
--
作者：
Brauer, VFH;Below, H;Paschke, R
目的：硫氰酸盐(SCN-)具有浓度依赖的抗甲状腺特性，已有多项研究表明其在甲状腺肿大的病因中起作用。1991年，在空气污染严重的哈勒/莱比锡(萨克森州)地区进行的一项流行病学调查表明，尿碘(I-)ISCN排泄量与甲状腺肿患病率呈负相关。10年后，我们重新调查了同一工业区，以澄清在消除大多数工业废物后，情况是否发生了变化，此外，SCN的排泄水平是否单独或与空气污染或吸烟作为SCN的来源对甲状腺功能至关重要。设计和方法：我们调查了708名病区尿样中I、SCN和肌酐排泄的先证者，并通过高分辨率超声确定甲状腺肿大和甲状腺结节的患病率。结果：79名甲状腺肿先证者，11%)的先证者尿SCN-排泄量显著高于无甲状腺疾病先证者(3.9+/-2.8vs3.1+/-3.4mgSCN-/g肌酐)，尿I-/SCn-比值显著低于无甲状腺疾病组(41+/-38vs61+/-71mgI-/mgSCN-/L)。有或无甲状腺肿大的先证者的平均尿氟排泄量没有差异。吸烟者与不吸烟者相比，尿SCN-/肌酐显著升高(4.3+/-4.3比2.4+/-2.1 mg SCN-/g肌酐)。方差分析揭示了甲状腺体积随年龄变化的预测(P<；0.001)。性别(P<；0.001)、体重(P<；005)和吸烟(P<；005)。结论：在我们的调查中，年龄、性别和吸烟(通过吸入CN提高SCN-水平)是甲状腺体积的预测因素，与单独尿氟排泄水平相比，尿I-/SCN-比率能够检测出患甲状腺肿风险全部增加的先证者。这些数据表明，在氰化物污染减少的所有时代和地区，SCN-可能仍然是甲状腺肿多因素病因中的一个辅助因素。
Objective: Thiocyanate (SCN-) has concentration dependent antithyroid properties and a role in the etiology of goiter has been Suggested in several Studies. In 1991 an epidemiological Survey conducted in the region of Halle/Leipzig (Saxony), an area with significant air Pollution, suggested an inverse relationship between urinary iodine (I-) ISCN- excretion and goiter prevalence. 10 years later, we reinvestigated the same industrial area to clarify if the situation has changed after the elimination of most industrial waste products and moreover, if SCN- excretion levels alone or in combination with air pollution or smoking as a SCN- source are critical for thyroid function.Design and methods: We investigated a cohort of 708 probands for I-, SCN- and creatinine excretion ill Spot Urine samples and determined the prevalence of goiter and thyroid nodules by high resolution ultrasonographyResults: Probands with goiter (n = 79, 11%) had significantly higher urinary SCN- excretions than probands without (3.9 +/- 2.8 vs 3.1 +/- 3.4 mg SCN-/g creatinine) and significantly lower urinary I-/SCN- ratios than patients without thyroid disorders (41 +/- 38 vs 61 +/- 71 mu g I-/mg SCN-/l). Mean urinary F excretions were not different between probands with or without goiter. Smokers showed significantly elevated urinary SCN-/creatinine ratios in comparison to non-smokers (4.3 +/- 4.3 vs 2.4 +/- 2.1 mg SCN-/g creatinine). ANOVA revealed a prediction of thyroid volume through age (P < 0.001). gender (P < 0.001), body weight (P < 0.05) and smoking (P < 0.05).Conclusions: In our investigation, age, gender and smoking (raising SCN- levels by CN- inhalation) were predictive for thyroid Volume and the urinary I-/SCN- ratios were able to detect probands with all increased risk of developing goiter in contrast to urinary F excretion levels alone. These data suggest, that in all era and area of decreased cyanide Pollution, SCN- may remain a cofactor in the multifactorial aetiology of goiter.