Mechanism of Visceral Fat Reduction in Tsumura Suzuki Obese, Diabetes (TSOD) Mice Orally Administered β-Cryptoxanthin from Satsuma Mandarin Oranges (Citrus unshiu Marc)
Mechanism of Visceral Fat Reduction in Tsumura Suzuki Obese, Diabetes (TSOD) Mice Orally Administered β-Cryptoxanthin from Satsuma Mandarin Oranges (Citrus unshiu Marc)
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DOI：
10.1021/jf202821u
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发表时间：
2011-12-14
影响因子：
6.1
通讯作者：
Ohnishi, Masao
中科院分区：
文献类型：
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作者：
Takayanagi, Katsuhiko;Morimoto, Sho-ichi;Ohnishi, Masao
类胡萝卜素 β-隐黄质 (β-CRX) 在萨摩柑橘 (Citrus unshiu Marc) 中含量丰富。多项研究表明，食用蜜柑与糖尿病、痛风和高血压等多种疾病的低风险之间存在关系，表明 β-CRX 参与疾病预防。我们研究了 β-CRX 对轻度肥胖男性的影响。 β-CRX 给药减少了内脏脂肪组织、体重和腹围。然而，β-CRX 介导这些变化的详细机制仍不清楚。为了确定这种机制，我们使用了肥胖模型小鼠（TSOD）。口服 β-CRX 给药可抑制 TSOD 中的体重、腹部脂肪组织重量和血清脂质浓度；这些结果与之前的人体试验结果相同。 β-CRX 给药显着抑制脂肪细胞肥大。基因表达分析强烈表明 β-CRX 可以改变细胞因子分泌和细胞增殖。这些结果表明，源自蜜柑的 β-CRX 可以通过抑制腹部脂肪细胞肥大来帮助预防肥胖。
The carotenoid beta-cryptoxanthin (beta-CRX) is abundant in Satsuma mandarins (Citrus unshiu Marc). Several studies have shown a relationship between Satsuma mandarin consumption and a low risk of several diseases, for example, diabetes, gout, and hypertension, suggesting beta-CRX involvement in disease prevention. We investigated the effect of beta-CRX on mildly obese males. beta-CRX administration reduced visceral adipose tissue, body weight, and abdominal circumference. However, the detailed mechanism by which beta-CRX mediates these changes remains unknown. To identify this mechanism, we used an obese model mouse (TSOD). Oral beta-CRX administration repressed body weight, abdominal adipose tissue weight, and serum lipid concentrations in TSOD; these results are identical to previous human trial results. beta-CRX administration significantly repressed adipocyte hypertrophy. Gene expression analysis strongly indicated that beta-CRX can alter cytokine secretion and cell proliferation. These results suggest that beta-CRX derived from Satsuma mandarins can help prevent obesity by repressing hypertrophy of abdominal adipocytes.