Extinction is not a sufficient condition to prevent fear memories from undergoing reconsolidation in the basolateral amygdala
Extinction is not a sufficient condition to prevent fear memories from undergoing reconsolidation in the basolateral amygdala
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DOI：
10.1111/j.1460-9568.2006.04907.x
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发表时间：
2006-07-01
影响因子：
3.4
通讯作者：
Nader, Karim
中科院分区：
文献类型：
--
作者：
Duvarci, Sevil;ben Mamou, Cyrinne;Nader, Karim
巩固的记忆在重新激活时可能会恢复到需要蛋白质合成才能重新稳定的状态（重新巩固）。在许多系统中已经证明，如果再激活引起显著的灭绝，那么灭绝是蛋白质合成依赖的记忆状态，而不是重新巩固。因此，消退巩固可能会阻止记忆进行再巩固。我们研究是否也存在这样的相互作用之间的灭绝和杏仁核内的恐惧记忆的重新巩固，通过使用受试者内的实验设计。我们发现，抑制基底外侧杏仁核（BLA）的蛋白质合成受损的再巩固的短暂重新激活和熄灭的恐惧记忆，这表明灭绝是不是一个足够的条件，以防止诱导杏仁核的再巩固。这些结果表明，灭绝巩固并不总是相互作用的再巩固。因此，在这些条件下，消退不是基底外侧杏仁核中恐惧记忆重新巩固的边界条件。
Consolidated memories when reactivated may return to a state that requires protein synthesis in order to be restabilized (reconsolidation). It has been shown in a variety of systems that if reactivation induces significant extinction then extinction is the protein synthesis dependent memory state, rather than reconsolidation. Thus, extinction consolidation may prevent the memory from undergoing reconsolidation. We investigated whether such an interaction also exists between extinction and reconsolidation of fear memories within the amygdala, by using a within subjects experimental design. We found that inhibition of protein synthesis in the basolateral amygdala (BLA) impaired reconsolidation for both the briefly reactivated and extinguished fear memories suggesting that extinction is not a sufficient condition to prevent induction of reconsolidation in the amygdala. These findings demonstrate that extinction consolidation does not always interact with reconsolidation. Therefore, under these conditions, extinction is not a boundary condition on reconsolidation of fear memories in the basolateral amygdala.