Metal-Organic-Framework-Engineered Enzyme-Mimetic Catalysts
Metal-Organic-Framework-Engineered Enzyme-Mimetic Catalysts
复制标题
金属有机骨架工程模拟酶催化剂
DOI：
10.1002/adma.202003065
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发表时间：
2020-10-30
影响因子：
29.4
通讯作者：
Qiu, Li
中科院分区：
文献类型：
--
作者：
Ma, Lang;Jiang, Fuben;Qiu, Li
基于纳米材料的酶模拟催化剂（Enz-Cats）由于其在不同生理环境中的优化和增强的催化性能和选择性而受到相当大的关注。近年来，金属有机骨架材料（MOFs）由于具有分子/原子水平的催化中心、高孔隙率、大比表面积、高负载量和均匀结构等特点，成为工程化酶催化剂的最有前途的材料之一。在这里，最近的进展，在设计的MOF工程酶猫，包括其制备方法，复合材料的构造，结构表征和生物医学应用，突出和评论。特别是，性能，选择性，基本机制，和潜在的结构-性能关系，这些MOF工程化的酶催化剂在加速催化反应进行了讨论。这些MOF工程酶猫的一些潜在的生物医学应用也简要提出。这些应用包括例如肿瘤治疗、细菌消毒、组织再生和生物传感器。最后，深入讨论了新兴研究前沿的未来机遇和挑战。因此，潜在的途径和前景，为设计未来国家的最先进的酶猫在生物医学科学提供。
Nanomaterial-based enzyme-mimetic catalysts (Enz-Cats) have received considerable attention because of their optimized and enhanced catalytic performances and selectivities in diverse physiological environments compared with natural enzymes. Recently, owing to their molecular/atomic-level catalytic centers, high porosity, large surface area, high loading capacity, and homogeneous structure, metal-organic frameworks (MOFs) have emerged as one of the most promising materials in engineering Enz-Cats. Here, the recent advances in the design of MOF-engineered Enz-Cats, including their preparation methods, composite constructions, structural characterizations, and biomedical applications, are highlighted and commented upon. In particular, the performance, selectivities, essential mechanisms, and potential structure-property relations of these MOF-engineered Enz-Cats in accelerating catalytic reactions are discussed. Some potential biomedical applications of these MOF-engineered Enz-Cats are also breifly proposed. These applications include, for example, tumor therapies, bacterial disinfection, tissue regeneration, and biosensors. Finally, the future opportunities and challenges in emerging research frontiers are thoroughly discussed. Thereby, potential pathways and perspectives for designing future state-of-the-art Enz-Cats in biomedical sciences are offered.