Photo- and Tetrazine-Responsive Modulation of trans-Zeatin.
Photo- and Tetrazine-Responsive Modulation of trans-Zeatin.
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DOI：
10.1021/acs.joc.2c02601
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发表时间：
2023-02
期刊：
影响因子：
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通讯作者：
Xin Sun;Li Liu;Liang Cheng
中科院分区：
文献类型：
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作者：
Xin Sun;Li Liu;Liang Cheng
光照射和有机小分子触发适当设计的笼状激素使得能够以高空间和时间分辨率控制和操纵相应的生物过程。合成了以硝基苯碳酸酯取代的笼状反式玉米素作为光可移除保护基团和反式环辛烯作为四嗪响应模体。已经实现了捕获的反式玉米素分子的平稳释放，允许对生物过程进行有针对性的扰动，包括降解、糖基化和被适当的酶识别。
Photoirradiation and small organic molecule triggering of appropriately designed caged hormones enable the control and manipulation of the corresponding biological processes with high spatial and temporal resolution. Caged trans-zeatin substituted with nitrobenzene carbonates as photoremovable protecting groups and trans-cyclooctene as the tetrazine-responsive motif have been synthesized. A smooth release of the trapped trans-zeatin molecule has been achieved, permitting targeted perturbation of biological processes, including degradation, glucosylation, and recognition by appropriate enzymes.