Mycotoxin-degradation profile of Rhodococcus strains
Mycotoxin-degradation profile of Rhodococcus strains
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DOI：
10.1016/j.ijfoodmicro.2013.06.002
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发表时间：
2013-08-16
影响因子：
5.4
通讯作者：
Kukolya, J.
中科院分区：
文献类型：
--
作者：
Cserhati, M.;Kriszt, B.;Kukolya, J.
真菌毒素是次生真菌代谢物，可能具有致突变、致癌、细胞毒性和内分泌干扰作用。尽管努力加以防止，但这些物质经常污染农产品，因此需要成功的解毒工具。应用微生物生物降解真菌毒素是一种在食品和饲料加工中具有应用潜力的新策略。本研究研究了32株红球菌对黄曲霉毒素B-1、玉米赤霉烯酮、伏马菌素B-1、T2毒素和赭曲霉毒素A等具有重要经济意义的真菌毒素的降解能力，并利用先前开发的毒性分析方法监测了黄曲霉毒素B-1和玉米赤霉烯酮降解过程和降解产物的安全性。此外，还通过实验分析了最佳解毒菌株对黄曲霉毒素B-1、玉米赤霉烯酮和T2毒素混合物的多重降解能力。这使得可以选择最安全、最有效的红球菌菌株，甚至可以用于多种真菌毒素的降解。我们认为，几种红球菌在芳香真菌毒素的降解中是有效的，它们在真菌毒素生物解毒过程中的应用是一个有前景的生物技术领域。(C) 2013 Elsevier B.V.版权所有
Mycotoxins are secondary fungal metabolites that may have mutagenic, carcinogenic, cytotoxic and endocrine disrupting effects. These substances frequently contaminate agricultural commodities despite efforts to prevent them, so successful detoxification tools are needed. The application of microorganisms to biodegrade mycotoxins is a novel strategy that shows potential for application in food and feed processing. In this study we investigated the mycotoxin degradation ability of thirty-two Rhodococcus strains on economically important mycotoxins: aflatoxin B-1, zearalenone, fumonisin B-1, T2 toxin and ochratoxin A, and monitored the safety of aflatoxin B-1 and zearalenone degradation processes and degradation products using previously developed toxicity profiling methods. Moreover, experiments were performed to analyse multi-mycotoxin-degrading ability of the best toxin degrader/detoxifier strains on aflatoxin B-1, zearalenone and T2 toxin mixtures. This enabled the safest and the most effective Rhodococcus strains to be selected, even for multi-mycotoxin degradation. We concluded that several Rhodococcus species are effective in the degradation of aromatic mycotoxins and their application in mycotoxin biodetoxification processes is a promising field of biotechnology. (C) 2013 Elsevier B.V. All rights reserved.