FISH OIL INCREASES PERIPHERAL CAPILLARY BLOOD-CELL VELOCITY IN HUMANS
FISH OIL INCREASES PERIPHERAL CAPILLARY BLOOD-CELL VELOCITY IN HUMANS
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DOI：
10.1016/0021-9150(87)90067-0
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发表时间：
1987-08-01
期刊：
影响因子：
5.3
通讯作者：
RICHARDSON, D
中科院分区：
文献类型：
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作者：
BRUCKNER, G;WEBB, P;RICHARDSON, D
含有n-3脂肪酸的鱼油已被证明在人体内可减少体外血小板聚集，降低血浆甘油三酯，并增加出血时间。鱼油对人体微循环血流的体内影响迄今尚未研究。21名男性受试者被随机分配到橄榄油（n = 10）或鱼油（n = 11）补充组，以确定这些油对甲襞区毛细血管血流速度（CBV）的影响。在单盲研究设计中，受试者被给予三周的油（1.5 g油/10 kg B.wt/天）。除了CBV血脂谱，血液粘度，血压和血小板和红细胞脂肪酸也确定之前和之后的饮食干预。鱼油补充显著增加CBV，增加1.75倍（0.144 ± 0.001）。0.069至0.253 ±。0.147 mm/s）。橄榄油组保持不变。与橄榄油补充组相比，在鱼的血小板和红细胞中注意到n-3脂肪酸水平增加。血液粘度在两组中没有改变，但是，橄榄油补充组的血压显著降低。补充鱼油组的血浆甘油三酯显著降低。这些观察结果表明，补充鱼油后CBV的增加是由于血管张力的变化，而不是血压或血液粘度的改变。
Fish oils containing n-3 fatty acids have been shown in humans to decrease platelet aggregation in vitro, lower plasma triglycerides, and to increase bleeding time. The in vivo effects of fish oils on microcirculatory blood flow in humans has not been studied to date. Twenty-one male subjects were randomly assigned to either olive oil (n = 10) or fish oil (n = 11) supplemented groups to determine the effects of these oils on capillary blood flow velocity (CBV) in the nailfold area. The subjects were given the oils for three weeks (1.5 g oil/10 kg b.wt/day) in a single blind study design. In addition to CBV plasma lipid profiles, blood viscosity, blood pressure and platelet and erythrocyte fatty acids were also determined prior to and after the dietary intervention. Fish oil supplementation significantly increased CBV, by 1.75-fold (0.144 .+-. 0.069 to 0.253 .+-. 0.147 mm/s). The olive oil group remained unchanged. Increased levels of n-3 fatty acids were noted in platelets and erythrocytes of the fish compared to olive oil-supplemented groups. Bood visocity was unaltered in both groups, however, blood pressure in the olive oil supplemented group was significantly decreased. Plasma triglycerides were significantly decreased in the fish oil supplemented group. These observations suggest that increases in CBV after fish oil supplementation are due to changes in vascular tone and not to alterations in blood pressure or blood viscosity.