In Situ Ligand-Directed Growth of Gold Nanoparticles in Biological Tissues.
In Situ Ligand-Directed Growth of Gold Nanoparticles in Biological Tissues.
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DOI：
10.1021/acs.nanolett.9b04911
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发表时间：
2020-02-12
期刊：
影响因子：
10.8
通讯作者：
Zheng J
中科院分区：
文献类型：
--
作者：
Peng C;Yu M;Zheng J
对复杂生物环境中纳米颗粒生长的基本理解和精确控制对于扩大其在组织成像中的潜在应用至关重要。本文中，我们报道了谷胱甘肽（GSH），一种在试管中广泛用于精确控制金纳米颗粒（AuNP）大小到单原子水平的盖层配体，也可用于指导组织中肾小管细胞线粒体和海马细胞中AuNP的选择性生长。精确控制这一生长过程可以形成具有近红外发光的超小型AuNPs和大型等离子体AuNPs。观察到的AuNPs的选择性生长可能是由于线粒体独特的谷胱甘肽储存功能。使用另一种配体β-葡萄糖硫醇，我们还发现用于葡萄糖吸收的肠刷状边界成为发光aunp生长的主要部位。这些发现表明，AuNPs在生物组织中的选择性生长确实可以通过特定的配体来指导，为组织标记和人工生物纳米杂交系统的未来发展开辟了新的途径。
Fundamental understandings and precise control of nanoparticle growth in the complex biological environment are crucial to broadening their potential applications in tissue imaging. Herein, we report that glutathione (GSH), a widely used capping ligand for precise control of the size of gold nanoparticle (AuNP) down to single-atom level in test tubes, can also be used to direct the selective growth of the AuNPs in the mitochondria of renal tubule cells as well as hippocampus cells in the tissues. Precise control of this growth process can lead to the formation of both ultrasmall AuNPs with near-infrared luminescence and large plasmonic AuNPs. The observed selective growth of the AuNPs is likely due to unique GSH storage function of the mitochondria. Using a different ligand, β-glucose thiol, we also found that the brush border of the intestine for glucose absorption became the major site for the growth of luminescent AuNPs. These findings suggest that selective growth of AuNPs in the biological tissues can indeed be directed with specific ligands, opening up a new avenue to tissue labeling and future development of artificial bionano hybrid systems.
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