A novel volumetric magnetic resonance imaging paradigm to study upper airway anatomy
A novel volumetric magnetic resonance imaging paradigm to study upper airway anatomy
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DOI：
10.1093/sleep/25.5.530
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发表时间：
2002-08-01
期刊：
影响因子：
5.6
通讯作者：
Schwab, RJ
中科院分区：
文献类型：
--
作者：
Welch, KC;Foster, GD;Schwab, RJ
研究目的：我们利用新的三维容积分析技术与磁共振成像（MRI）研究上气道和周围的软组织结构。这些MRI技术使我们能够客观地量化舌头、软腭、咽旁脂肪垫和咽侧壁的体积。设计：我们首先在体模上验证了我们的体积成像技术，然后证明我们的结果在没有减肥的正常受试者中是可靠且可重复的。最后，我们研究了12名肥胖，无呼吸暂停的妇女在清醒之前和之后的减肥。我们假设我们的新型磁共振计算机重建技术将使我们能够检测到体重减轻时舌、软腭、咽侧壁和咽旁脂肪垫体积的微小减少以及上气道体积的增加。设置：大学医学中心参与者：正常对照组和12名肥胖非呼吸暂停女性干预：体重减轻测量和结果：平均体重为17.1 +/-8.62 kg（17.3%）体重减轻，上气道容积增加（p = 0.06）在腭后和舌后区，上呼吸道容积的增加是由咽侧壁容积的显著减少介导的（p = 0.0001）和咽旁脂肪垫（p = 0.001）。然而，舌（p = 0.35）和软腭（p = 0.39）的体积并没有随着体重减轻而显著减少。结论：这些数据表明，体积MRI是研究上气道和周围软组织结构解剖变化的有力工具，并且足够敏感以检测这些结构的变化。
Study Objectives: We utilized novel three-dimensional volumetric analysis techniques with magnetic resonance imaging (MRI) to study the upper airway and surrounding soft-tissue structures. These MRI techniques allowed us to objectively quantify the volume of the tongue, soft palate, parapharyngeal fat pads, and lateral pharyngeal walls.Design: We first validated our volumetric imaging techniques on a phantom and then demonstrated that our results were reliable and reproducible in normal subjects who did not lose weight. Finally, we studied 12 obese, nonapneic women during wakefulness before and after weight loss. We hypothesized that our novel magnetic-resonance computer-reconstruction techniques would allow us to detect small reductions in the volume of the tongue, soft palate, lateral pharyngeal walls, and parapharyngeal fat pads and increases in the volume of the upper airway with weight loss,Setting: University medical centerParticipants: Normal controls and 12 obese nonapneic womenInterventions: Weight lossMeasurements and Results: Following a mean 17.1 +/- 8,62 kg (17.3%) reduction in weight, upper airway volume increased (p = 0.06) in both the retropalatal and retroglossal regions, This increase in upper airway volume was mediated by significant reductions in the volume of the lateral pharyngeal wall (p = 0.0001) and parapharyngeal fat pads (p = 0.001). However, the volume of the tongue (p = 0,35) and soft palate (p = 0,39) were not reduced significantly with weight loss,Conclusions: These data indicate that volumetric MRI is a powerful tool to study anatomic changes in the upper airway and surrounding soft-tissue structures and is sensitive enough to detect changes in these structures.