Long term prognosis of fatty liver: risk of chronic liver disease and death
Long term prognosis of fatty liver: risk of chronic liver disease and death
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DOI：
10.1136/gut.2003.019984
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发表时间：
2004-05-01
期刊：
影响因子：
24.5
通讯作者：
Bendtsen, F
中科院分区：
文献类型：
--
作者：
Dam-Larsen, S;Franzmann, M;Bendtsen, F
背景和目的：脂肪肝是人类肝活检标本中常见的组织学发现。它影响10-24%的一般人群，被认为是晚期慢性肝病风险的标志。本研究探讨的风险发展的脂肪肝疾病和死亡的风险，在一个队列诊断为纯脂肪肝无inflations.Methods：共215例患者在1976年至1987年期间进行了肝活检被列入研究。该人群包括109名非酒精性脂肪肝患者和106名酒精性脂肪肝患者。非酒精组的中位随访时间为16.7（0.2-21.9）年，酒精组为9.2（0.6-23.1）年。通过审查所有病历进行系统数据收集。研究队列的所有成员通过其唯一的个人识别号码联系到国家登记处的患者和全国登记处的死因，和所有的入院，出院诊断，并获得死因were given.Results：在非酒精性脂肪肝组，一名患者发展为肝硬化在随访期间相比，22名患者在酒精组。生存率估计值显著（p
Background and aims: Fatty liver is a common histological finding in human liver biopsy specimens. It affects 10-24% of the general population and is believed to be a marker of risk of later chronic liver disease. The present study examined the risk of development of cirrhotic liver disease and the risk of death in a cohort diagnosed with pure fatty liver without inflammation.Methods: A total of 215 patients who had a liver biopsy performed during the period 1976-1987 were included in the study. The population consisted of 109 non-alcoholic and 106 alcoholic fatty liver patients. Median follow up time was 16.7 (0.2-21.9) years in the non-alcoholic and 9.2 (0.6-23.1) years in the alcoholic group. Systematic data collection was carried out by review of all medical records. All members of the study cohort were linked through their unique personal identification number to the National Registry of Patients and the nationwide Registry of Causes of Death, and all admissions, discharge diagnoses, and causes of death were obtained.Results: In the non-alcoholic fatty liver group, one patient developed cirrhosis during the follow up period compared with 22 patients in the alcoholic group. Survival estimates were significantly (p