A LIBRETTO to orchestrate targeted therapy.
A LIBRETTO to orchestrate targeted therapy.
复制标题
精心策划靶向治疗的剧本。
DOI：
10.1038/s43018-020-00144-x
复制
发表时间：
2020
期刊：
影响因子：
22.7
通讯作者：
Aggarwal,Charu
中科院分区：
文献类型：
--
作者：
Marmarelis,MelinaE;Chiarle,Roberto;Ambrogio,Chiara;Aggarwal,Charu
尽管RET改变在肿瘤类型中相对频繁，但在临床中特异性靶向RET一直具有挑战性。Ambrogio，Aggarwal及其同事在最近的两项临床研究中就机制研究如何迅速转化为强大的靶向治疗提供了他们的观点，这两项临床研究导致FDA批准selpercatinib用于某些RET改变的肿瘤。
Although RET alterations are relatively frequent across tumor types, specific targeting of RET in the clinic has been challenging. Ambrogio, Aggarwal and colleagues provide their views on how mechanistic studies have swiftly translated into powerful targeted therapies in two recent clinical studies that led to the FDA approval of selpercatinib for certain tumors in which RET is altered.