2p or not 2p: tuppence-based SERS for the detection of illicit materials
2p or not 2p: tuppence-based SERS for the detection of illicit materials
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DOI：
10.1039/c2an35974j
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发表时间：
2013-01-01
期刊：
影响因子：
4.2
通讯作者：
Goodacre, Royston
中科院分区：
文献类型：
--
作者：
Mabbott, Samuel;Eckmann, Alex;Goodacre, Royston
已证明，在英国2便士硬币上沉积银是一种高效且具有成本效益的方法，可以生产能够促进表面增强拉曼散射（Sers）的基底。银在铜币上的应用要求不高，仅需20 s，并导致形成多个层次的树枝状结构。为了证明银沉积位点能够Sers，使用了高荧光罗丹明6 G（R6 G）探针。分析表明，拉曼增强只发生在银沉积位点，而不是从粗糙的铜表面。然后探讨了底物在识别和区分非法和法律的滥用药物中的稳健性。使用点样和浸泡方法将药物应用于基底。虽然在点样时很少或没有产生药物的Sers光谱，但将底物浸泡在药物的甲醇溶液中产生了大量的光谱信息。使用主成分分析和偏最小二乘法证明了Sers方法和三种药物，4-甲基甲卡西酮（甲氧麻黄酮），5，6-亚甲二氧基-2-氨基茚满（MDAI）和3，4-亚甲二氧基-N-甲基苯丙胺（MDMA）的分类的良好再现性。
Deposition of silver onto British 2p coins has been demonstrated as an efficient and cost effective approach to producing substrates capable of promoting surface enhanced Raman scattering (SERS). Silver application to the copper coins is undemanding taking just 20 s, and results in the formation of multiple hierarchial dendritic structures. To demonstrate that the silver deposition sites were capable of SERS the highly fluorescent Rhodamine 6G (R6G) probe was used. Analyses indicated that Raman enhancement only occurs at the silver deposition sites and not from the roughened copper surface. The robustness of the substrate in the identification and discrimination of illegal and legal drugs of abuse was then explored. Application of the drugs to the substrates was carried out using spotting and soaking methodologies. Whilst little or no SERS spectra of the drugs were generated upon spotting, soaking of the substrate in a methanolic solution of the drugs yielded a vast amount of spectral information. Excellent reproducibility of the SERS method and classification of three of the drugs, 4-methylmethcathinone (mephedrone), 5,6-methylenedioxy-2-aminoindane (MDAI) and 3,4-methylenedioxy-N-methylamphetamine (MDMA) were demonstrated using principal components analysis and partial least squares.