ORGANIZATION OF MOSSY FIBER SYSTEM OF RAT STUDIED IN EXTENDED HIPPOCAMPI .1. TERMINAL AREA RELATED TO NUMBER OF GRANULE AND PYRAMIDAL CELLS
ORGANIZATION OF MOSSY FIBER SYSTEM OF RAT STUDIED IN EXTENDED HIPPOCAMPI .1. TERMINAL AREA RELATED TO NUMBER OF GRANULE AND PYRAMIDAL CELLS
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DOI：
10.1002/cne.901780104
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发表时间：
1978-01-01
影响因子：
2.5
通讯作者：
GAARSKJAER, FB
中科院分区：
文献类型：
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作者：
GAARSKJAER, FB
对大鼠海马苔藓纤维系统的间隔颞叶组织进行了定量和定性研究。根据尼氏或蒂姆氏方法对分离和延伸的海马的横切面进行染色。在覆盖整个海马体长度的 12 个等距水平处测量以下参数：颗粒细胞层和苔藓纤维层的长度、包含苔藓纤维束的区域的面积、门和下区域中颗粒细胞的数量和锥体细胞的数量。间隔下区域的锥体层较宽，层内细胞间隔相对较宽。在这里，苔藓纤维束深入到该层中。在更时间的水平上，细胞紧密堆积，细胞层更窄，并且纽扣主要终止于锥体上。颗粒层的间隔长度最大；苔藓纤维层的长度暂时最大。门的面积被苔藓纤维束占据，在颞部水平的大部分区域较大，而在间隔水平则较小；在 CA3 中则相反。在隔膜水平处发现最多数量的颗粒细胞。相反，门和下区的大多数锥体细胞位于颞部。颗粒细胞与锥体细胞（门和下区一起）的比率从间隔水平的大约 10 线性下降到颞水平的大约 1。由于苔藓纤维分布相当横向于海马长轴，颗粒细胞与锥体细胞比例的变化反映了苔藓纤维系统内神经支配细胞数量的相应变化。
A quantitative and qualitative study of the septotemporal organization of the hippocampal mossy fiber system was conducted in the rat. Transverse sections of isolated and extended hippocampi were stained according to Nissl''s or Timm''s method. At 12 equidistant levels covering the entire length of the hippocampus the following parameters were measured: the length of the granule cell layer and the mossy fiber layer, the area of the fields containing mossy fiber boutons, the number of granule cells and the number of pyramidal cells in the hilus and in the regio inferior. Septally the pyramidal layer of the regio inferior is broad and the cells within the layer are relatively widely spaced. Here the mossy fiber boutons intrude deep into the layer. At more temporal levels the cells are tightly packed, the cell-layer is narrower and the boutons predominantly terminate suprapyramidally. The length of the granular layer is greatest septally; the length of the mossy fiber layer is greatest temporally. The area of the hilus, occupied by the mossy fiber boutons, is large at most of the temporal levels and small at the septal levels; in CA3 the reverse is true. The greatest number of granule cells were found at the more septal levels. Conversely, the majority of the pyramidal cells in the hilus and in the regio inferior are situated temporally. The ratio of granule cells to pyramidal cells (hilus and regio inferior together), declines linearly from approximately 10 at septal levels to approximately 1 at temporal levels. Because the mossy fibers are distributed fairly transversely to the long axis of the hippocampus, the variation in the ratio of granule cells to pyramidal cells reflects a corresponding variation in the number of innervating to innervated cells within the mossy fiber system.