The yeast replicative aging model
The yeast replicative aging model
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DOI：
10.1016/j.bbadis.2018.02.023
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发表时间：
2018-09-01
影响因子：
6.2
通讯作者：
Kennedy, Brian K.
中科院分区：
文献类型：
--
作者：
He, Chong;Zhou, Chuankai;Kennedy, Brian K.
发芽酵母酿酒酵母成为衰老研究的重要模式生物已有近三十年的时间，它的出现既简单又强大。复制衰老试验是这些研究中的一项重要内容，它通过询问“母”细胞分裂和产生“女儿”的次数来确定数百个影响寿命的基因。最近，细胞生物学和生化方法被开发出来，以确定细胞过程如何随着年龄的变化而改变。总而言之，这些工具已经到位，可以对这种单细胞有机体的衰老形成一个整体的看法。在这里，我们总结了对酵母复制老化的理解现状，重点介绍了最近的研究，这些研究揭示了老化途径如何相互作用来调节酵母的寿命。
It has been nearly three decades since the budding yeast Saccharomyces cerevisiae became a significant model organism for aging research and it has emerged as both simple and powerful. The replicative aging assay, which interrogates the number of times a "mother" cell can divide and produce "daughters", has been a stalwart in these studies, and genetic approaches have led to the identification of hundreds of genes impacting lifespan. More recently, cell biological and biochemical approaches have been developed to determine how cellular processes become altered with age. Together, the tools are in place to develop a holistic view of aging in this single-celled organism. Here, we summarize the current state of understanding of yeast replicative aging with a focus on the recent studies that shed new light on how aging pathways interact to modulate lifespan in yeast.