Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case-control study
Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case-control study
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DOI：
10.1111/j.1365-2133.2007.07986.x
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发表时间：
2007-07-01
影响因子：
10.3
通讯作者：
Girolomoni, G.
中科院分区：
文献类型：
--
作者：
Gisondi, P.;Tessari, G.;Girolomoni, G.
背景银屑病是一种慢性炎症性疾病，与心血管风险增加相关。代谢综合征是心血管事件的重要预测因子。目的探讨银屑病患者代谢综合征的患病率。方法对338例慢性斑块状银屑病患者和334例非银屑病皮肤病患者进行以医院为基础的病例对照研究。结果银屑病患者代谢综合征的发生率明显高于对照组（30.1% vs. 20.6%，比值比1.65，95%置信区间1.16-2.35; P = 0.005）。银屑病患者高脂血症和腹部肥胖的患病率也较高，而高脂血症、动脉高血压和高密度脂蛋白胆固醇血浆水平相似。虽然银屑病患者更常吸烟，但银屑病与代谢综合征的关联与吸烟无关。银屑病的严重程度与代谢综合征的患病率之间无相关性。结论银屑病患者代谢综合征的患病率较高，易发生心血管事件。我们建议应鼓励银屑病患者积极纠正其可改变的心血管危险因素。
Background Psoriasis is a chronic inflammatory disease associated with an increased cardiovascular risk. Metabolic syndrome is a significant predictor of cardiovascular events.Objective To investigate the prevalence of metabolic syndrome in patients with psoriasis.Methods We performed a hospital-based case-control study on 338 adult patients with chronic plaque psoriasis and 334 patients with skin diseases other than psoriasis.Results Metabolic syndrome was significantly more common in psoriatic patients than in controls (30.1% vs. 20.6%, odds ratio 1.65, 95% confidence interval 1.16-2.35; P = 0.005) after the age of 40 years. Psoriatic patients also had a higher prevalence of hypertriglyceridaemia and abdominal obesity, whereas hyperglycaemia, arterial hypertension and high-density lipoprotein cholesterol plasma levels were similar. Although psoriasis patients were more frequently smokers, the association of psoriasis with metabolic syndrome was independent from smoking. There was no correlation between severity of psoriasis and prevalence of metabolic syndrome. Psoriatic patients with metabolic syndrome were older and had a longer disease duration compared with psoriatic patients without metabolic syndrome.Conclusion Psoriatic patients have a higher prevalence of metabolic syndrome, which can favour cardiovascular events. We suggest psoriatic patients should be encouraged to correct aggressively their modifiable cardiovascular risk factors.