Inhibitory effects of neuropeptide Y on sympathetic neurotransmission in the rabbit iris-ciliary body.
Inhibitory effects of neuropeptide Y on sympathetic neurotransmission in the rabbit iris-ciliary body.
复制标题
神经肽 Y 对兔虹膜睫状体交感神经传递的抑制作用。
DOI：
10.1007/bf00968668
复制
发表时间：
1990
影响因子：
4.4
通讯作者：
Jumblatt,JE
中科院分区：
文献类型：
--
作者：
Ohia,SE;Jumblatt,JE
Neuropeptide Y (NPY, 1–300 nM) mediated a concentration-dependent inhibition of field stimulation-evoked [3H]norepinephrine (NE) overflow from the isolated, superfused rabbit iris-ciliary body. At equimolar concentrations (100 nM), the homologous neuropeptide peptide YY (PYY) mimicked the effects of NPY, whereas pancreatic polypeptide (PP) and the C-terminal fragment of NPY16–36did not modify [3H]NE release. NPY-induced inhibition of [3H]NE release was unaffected by pretreatment of tissues with atropine (100 nM) plus yohimbine (100 nM) and was nonadditive with the maximal prejunctional effects of carbamycholine or clonidine, indicating that NPY acts independently of prejunctional muscarinic or alpha2-adrenergic receptor activity to reduce [3H]NE overflow. It is concluded that NPY is a specific, potent modulator of adrenergic neurosecretion in the rabbit iris-ciliary body. These findings confirm the role of NPY as a co-transmitter at ocular sympathetic neuroeffector junctions, either mimicking or augmenting the actions of endogenously released norepinephrine.
