Initial bone regeneration around fenestrated implants in Beagle dogs using basic fibroblast growth factor-gelatin hydrogel complex with varying biodegradation rates
Initial bone regeneration around fenestrated implants in Beagle dogs using basic fibroblast growth factor-gelatin hydrogel complex with varying biodegradation rates
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DOI：
10.1016/j.jpor.2008.08.009
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发表时间：
2009-01-01
影响因子：
3.6
通讯作者：
Tabata, Yasuhiko
中科院分区：
文献类型：
--
作者：
Akagawa, Yasumasa;Kubo, Takayasu;Tabata, Yasuhiko
目的：本研究的目的是比较碱性成纤维细胞生长因子 (bFGF) 明胶水凝胶复合物作为一种新型增强药物输送系统，快速和缓慢生物降解对有孔种植体周围骨再生的有效性。方法：将 9 个钛种植体（直径 3.3 毫米，长度 10 毫米）置入三只成年比格犬下颌骨无牙颌区域，并在上颊侧暴露四个螺钉。将不同降解类型的bFGF-明胶水凝胶复合物用于覆盖无膜种植螺钉的有效性与作为快速降解类型的1μmg和10μgbFGF-98wt％明胶和作为慢速降解类型的10μgbFGF-95wt％明胶进行比较。 4周后，对螺钉周围的骨再生进行组织学和组织形态计量学评估。结果：使用10μg bFGF，在快速和慢速降解型组中，暴露的螺钉周围的再生骨都清晰可见。相反，在1mg bFGF的快速降解型组中几乎没有看到骨形成。慢速降解型bFGF复合物组的再生骨高度显着大于快速降解型bFGF组（P < 0.05）。结论：这些结果表明，使用慢速降解型bFGF-明胶水凝胶复合物可以在骨再生的早期加速有孔种植体周围的骨再生。 (C) 2009 年由爱思唯尔爱尔兰公司代表日本修复协会出版。
Purpose: The purpose of this study was to compare the effectiveness of fast and slow biodegradation of basic fibroblast growth factor (bFGF)gelatin hydrogel complex on bone regeneration around fenestrated implants as a new augmentation drug delivery system.Methods: Nine titanium implants (3.3 mm diameter and 10 mm length) were placed into the edentulous areas of the mandibles of three adult beagle dogs with four screws exposed at the upper buccal side. The effectiveness of bFGF- gelatin hydrogel complexes of varying degradation types used to cover implant screws without membrane were compared with 1 mu mg and 10 mu g bFGF- 98 wt% gelatin as the fast degradation type and 10 mu g bFGF- 95 wt% gelatin as the slow degradation type. After 4 weeks, bone regeneration around the screws was evaluated histologically and histomorphometrically.Results: With use of 10 mu g bFGF, regenerated bone around exposed screws was clearly seen in both the fast and slow degradation type groups. In contrast, little bone formation was seen in the fast degradation-type group with 1 mg bFGF. Height of regenerated bone for the slow degradation-type complex group was significantly greater than for the fast degradation-type group with 1 mu g bFGF (P < 0.05).Conclusion: These results suggest that use of slow degradation-type bFGF- gelatin hydrogel complex may accelerate bone regeneration around fenestrated implants at an early stage of bone regeneration. (C) 2009 Published by Elsevier Ireland on behalf of Japan Prosthodontic Society.