Functions of the Large Maf Transcription Factors and Macrophages
Functions of the Large Maf Transcription Factors and Macrophages
复制标题
大 Maf 转录因子和巨噬细胞的功能
DOI：
10.1007/978-1-4939-1311-4_25
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Satoru Takahashi
中科院分区：
文献类型：
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作者：
Michito Hamada;Satoru Takahashi
Maf转录因子是一组具有碱性亮氨酸拉链(bZIP)结构并识别称为Maf识别元件(MARE)的DNA序列的转录因子。在Maf转录因子中，MafB和c-Maf在巨噬细胞中表达，它们对于调节巨噬细胞的基本功能（例如吞噬凋亡细胞、促进细胞存活、产生细胞因子和控制巨噬细胞群）至关重要。此外，MafB 调节单巨噬细胞谱系细胞（巨噬细胞、树突细胞和破骨细胞）的平衡。因此，MafB和c-Maf是两个关键的转录因子，在调节巨噬细胞的生成和功能中发挥重要作用。
Maf transcription factors are a group of transcription factors which possess the basic and leucine zipper (bZIP) structure and recognize a DNA sequence called Maf recognition element (MARE). Among the Maf transcription factors, MafB and c-Maf are expressed in the macrophages, where they are essential for regulating the fundamental functions of macrophages such as phagocytosis of apoptotic cells, promotion of cell survival, production of cytokines, and control of macrophage population. In addition, MafB regulates the balance of mono-macrophage lineage cells—the macrophages, dendritic cells, and osteoclasts. Thus, MafB and c-Maf are the two key transcription factors which play important roles in regulating the generation and function of macrophages.