A highly sensitive ratiometric fluorescent probe with a large emission shift for imaging endogenous cysteine in living cells.
A highly sensitive ratiometric fluorescent probe with a large emission shift for imaging endogenous cysteine in living cells.
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DOI：
10.1016/j.bios.2013.11.068
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发表时间：
2014-05
影响因子：
12.6
通讯作者：
Baocun Zhu;Bingpeng Guo;Yunzhou Zhao;Bing Zhang;B. Du
中科院分区：
文献类型：
--
作者：
Baocun Zhu;Bingpeng Guo;Yunzhou Zhao;Bing Zhang;B. Du
提出了一种构建大发射位移比率荧光探针的新设计策略。基于这一策略，合成了一种具有117 nm红移发射的半胱氨酸(Cys)的高选择性、高灵敏度的比色和比率荧光探针，并将其应用于活细胞内源性Cys的比率成像。
A new design strategy for the construction of ratiometric fluorescent probe with a large emission shift was developed. Based on this strategy, a highly selective and sensitive colorimetric and ratiometic fluorescent probe for cysteine (Cys) with a 117 nm red-shifted emission was synthesized and applied to the ratiometric imaging of endogenous Cys in living cells.