Ventricular Function in Cardiac‐Denervated and Cardiac‐Sympathectomized Conscious Dogs
Ventricular Function in Cardiac‐Denervated and Cardiac‐Sympathectomized Conscious Dogs
复制标题
心脏去神经支配和心脏交感神经切除的清醒犬的心室功能
作者：
H. L. Stone;V. S. Bishop;E. Dong
在清醒的动物中研究了心脏神经或心脏交感神经被消除时自主神经系统在心室功能中的作用。局部神经消融用于去神经支配心脏，并与心得安进行心脏交感神经阻滞。与对照曲线的318 ml/min/kg相比，在心脏去神经动物（263 ml/min/kg）和β受体阻滞动物（240 ml/min/kg）中观察到心室输出的平台降低。心脏去神经动物和β-阻滞动物在平台期的每搏输出量的差异表明，慢性心脏去神经动物仅通过每搏输出量的变化来改变其心室输出量，而β-阻滞动物则响应于应激而改变心率和每搏输出量。因此，β受体阻滞的动物通过减少副交感神经活动来增加心率。
The role of the autonomic nervous system in ventricular function was studied in conscious animals when either the cardiac nerves or the sympathetic nerves to the heart had been eliminated. Regional neural ablation was used to denervate the heart, and blockade of the cardiac sympathetic nerves was performed with propranolol. A reduction in the plateau of the ventricular output was seen in the cardiac-denervated animals (263 ml/min per kg) and in animals with beta-blockade (240 ml/min per kg) as compared with 318 ml/min per kg for the control curves. The difference in stroke volume in the cardiac-denervated animals and the beta-blocked animals at the plateau demonstrates that the chronically cardiac-denervated animal changes its ventricular output solely by a change in stroke volume, whereas the animal with beta-blockade changes heart rate and stroke volume in response to stress. Thus the beta-blocked animals increased their heart rate by a decrease in parasympathetic activity.