GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
复制标题
GEPIA2：用于大规模表达谱和交互式分析的增强型 Web 服务器
DOI：
10.1093/nar/gkz430
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发表时间：
2019-07-02
影响因子：
14.9
通讯作者：
Zhang, Zemin
中科院分区：
文献类型：
--
作者：
Tang, Zefang;Kang, Boxi;Zhang, Zemin
GEPIA（基因表达谱交互式分析）网络服务器于2017年推出，是基于TCGA和GTEx数据库中肿瘤和正常样本进行基因表达分析的宝贵和高引用资源。在这里，我们介绍了GEPIA 2，这是一个更新和增强的版本，可以提供更高分辨率和更多功能的见解。GEPIA 2具有198 619种亚型和84种癌症亚型，将基因表达定量从基因水平扩展到转录水平，并支持特定癌症亚型的分析和亚型之间的比较。此外，GEPIA 2还采用了受单细胞测序研究启发的基因特征定量新分析技术，并提供定制分析，用户可以上传自己的RNA-seq数据，并将其与TCGA和GTEx样本进行比较。我们还提供了一个API用于批量处理和轻松检索分析结果。更新后的网络服务器可在http://gepia2.cancer-pku.cn/上公开访问。
Introduced in 2017, the GEPIA (Gene Expression Profiling Interactive Analysis) web server has been a valuable and highly cited resource for gene expression analysis based on tumor and normal samples from the TCGA and the GTEx databases. Here, we present GEPIA2, an updated and enhanced version to provide insights with higher resolution and more functionalities. Featuring 198 619 isoforms and 84 cancer subtypes, GEPIA2 has extended gene expression quantification from the gene level to the transcript level, and supports analysis of a specific cancer subtype, and comparison between subtypes. In addition, GEPIA2 has adopted new analysis techniques of gene signature quantification inspired by single-cell sequencing studies, and provides customized analysis where users can upload their own RNA-seq data and compare them with TCGA and GTEx samples. We also offer an API for batch process and easy retrieval of the analysis results. The updated web server is publicly accessible at http://gepia2.cancer-pku.cn/.