Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients.
Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients.
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检测一组用于 HLA-A31 上皮癌患者的候选肽疫苗。
DOI：
10.3892/ijo.24.2.337
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发表时间：
2004
影响因子：
5.2
通讯作者：
K. Itoh
中科院分区：
文献类型：
--
作者：
H. Takedatsu;S. Shichijo;K. Azuma;H. Takedatsu;M. Sata;K. Itoh
HLA-A31+癌症患者宿主-肿瘤相互作用的分子基础尚未得到充分了解。缺乏澄清阻碍了针对这些患者的特异性免疫疗法的开发。本研究旨在鉴定一组适用于HLA-A31等位基因癌症患者特异性免疫治疗的CTL表位肽。 HLA-A31等位基因在世界人口的5-10%中表达，其中在巴西美洲人中表达最高（65%），在爱斯基摩人中表达最低（0%）。我们在此报道了编码 CTL 表位和 7 个表位肽的 4 个 cDNA，它们能够诱导 HLA-A31 限制性 CTL 对 HLA-A31+ 癌症患者外周血单核细胞中的肿瘤细胞系具有细胞毒性。这些肽可能有助于开发针对 HLA-A31+ 癌症患者的基于肽的免疫疗法。
The molecular basis of host-tumor interaction in HLA-A31+ cancer patients has not been well understood. This lack of clarification is hampering the development of specific immunotherapies for these patients. This study aimed to identify a set of CTL-epitope peptides applicable for the specific immunotherapy of cancer patients with HLA-A31 allele. HLA-A31 allele is expressed in 5-10% of the world population, with the highest expression among Brazilian Amerinds (65%), and the lowest in the Eskimo population (0%). We report herein four cDNAs encoding CTL-epitopes and 7 epitope peptides with the ability to induce HLA-A31-restricted CTLs cytotoxic to tumor cell lines in the peripheral blood mononuclear cells of HLA-A31+ cancer patients. These peptides might be useful for the development of a peptide-based immunotherapy for HLA-A31+ cancer patients.