Arterial compliance and its control by the baroreflex in hypertensive dogs.
Arterial compliance and its control by the baroreflex in hypertensive dogs.
复制标题
高血压犬的动脉顺应性及其压力反射的控制。
DOI：
10.1152/ajpheart.1993.265.2.h616
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Shigemi,K
中科院分区：
文献类型：
--
作者：
Brunner,MJ;Bishop,GG;Shigemi,K
在正常血压和Goldblatt高血压犬中测试颈动脉压力感受性反射对全身动脉顺应性的影响。在实验性高血压形成后，用戊巴比妥钠将狗急性麻醉并切断迷走神经。然后分离颈动脉窦并保持在50、125和200 mmHg的受控颈动脉窦压力（CSP）下。将狗置于恒定流量、恒定静脉压、心肺转流。动脉顺应性是从动脉压指数下降的时间常数确定的，当血流在三个不同的CSP水平停止时发生。高血压组的反射特征曲线（平均动脉压vs. CSP）上移和右移。动脉顺应性显着降低CSP，但在任何给定的CSP水平，动脉顺应性是没有不同的血压正常和高血压组。非线性分析表明，动脉顺应性动脉压的关系没有改变Goldblatt实验性高血压。本研究的结果表明，动脉顺应性主要是动脉压的绝对水平的函数。动脉顺应性的压力反射控制在较低水平的动脉压下是重要的。
The effect of the carotid baroreflex on systemic arterial compliance was tested in normotensive and Goldblatt hypertensive dogs. After the development of experimental hypertension, dogs were acutely anesthetized with pentobarbital sodium and vagotomized. The carotid sinuses were then isolated and held at controlled carotid sinus pressures (CSP) of 50, 125, and 200 mmHg. The dogs were placed on constant flow, constant venous pressure, cardiopulmonary bypass. Arterial compliance was determined from the time constant of the exponential fall in arterial pressure, which occurred when the flow was stopped at three different levels of CSP. The reflex characteristic curve (mean arterial pressure vs. CSP) was shifted upward and to the right in the hypertensive group. Arterial compliance significantly decreased with decreasing CSP, but at any given level of CSP, arterial compliance was not different in the normotensive and hypertensive groups. A nonlinear analysis revealed that the arterial compliance-arterial pressure relationship was not altered by Goldblatt experimental hypertension. The results of this study indicate that the arterial compliance is primarily a function of the absolute level of arterial pressure. Baroreflex control of arterial compliance is important at lower levels of arterial pressure.