Oocyte-granulosa-theca cell interactions during preantral follicular development.
Oocyte-granulosa-theca cell interactions during preantral follicular development.
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DOI：
10.1186/1757-2215-2-9
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发表时间：
2009-07-09
影响因子：
4
通讯作者：
Kotsuji F
中科院分区：
文献类型：
--
作者：
Orisaka M;Tajima K;Tsang BK;Kotsuji F
就促性腺激素依赖性和卵泡命运（生长与闭锁）而言，窦前-早期窦卵泡转换是卵泡发育的倒数第二个阶段。在此期间，卵泡的生长受到卵母细胞-颗粒细胞-卵泡膜细胞相互作用的严格调控。卵泡膜细胞层的形成是在这个过渡阶段发生的关键事件。颗粒因子刺激从皮质基质细胞募集卵泡膜细胞，而卵母细胞衍生的生长分化因子-9（GDF-9）参与卵泡发育早期卵泡膜细胞的分化。窦前至早期窦的过渡期最易发生卵泡闭锁。GDF-9通过抑制颗粒细胞凋亡和卵泡闭锁促进卵泡从窦前期向早期窦期过渡期间的存活和生长。GDF-9还通过上调卵泡膜细胞雄激素的产生来增强腔前卵泡的生长。卵泡膜因子促进颗粒细胞增殖并抑制颗粒细胞凋亡。了解卵巢内卵泡生长和闭锁的调控机制，对选择最优质的生殖细胞进行辅助生殖可能具有临床意义。此外，由于某些卵巢功能障碍，如多囊卵巢综合征和促性腺激素低反应性，是在这个过渡阶段的卵泡生长失调的后果，了解在控制卵泡发育的分子和细胞机制，在前窦早期窦过渡可能提供重要的洞察这些条件的病理生理和合理的治疗。
The preantral-early antral follicle transition is the penultimate stage of follicular development in terms of gonadotropin dependence and follicle destiny (growth versus atresia). Follicular growth during this period is tightly regulated by oocyte-granulosa-theca cell interactions. Formation of the theca cell layer is a key event that occurs during this transitional stage. Granulosal factor(s) stimulates the recruitment of theca cells from cortical stromal cells, while oocyte-derived growth differentiation factor-9 (GDF-9) is involved in the differentiation of theca cells during this early stage of follicular development. The preantral to early antral transition is most susceptible to follicular atresia. GDF-9 promotes follicular survival and growth during transition from preantral stage to early antral stage by suppressing granulosa cell apoptosis and follicular atresia. GDF-9 also enhances preantral follicle growth by up-regulating theca cell androgen production. Thecal factor(s) promotes granulosa cell proliferation and suppress granulosa cell apoptosis. Understanding the intraovarian mechanisms in the regulation of follicular growth and atresia during this stage may be of clinical significance in the selection of the best quality germ cells for assisted reproduction. In addition, since certain ovarian dysfunctions, such as polycystic ovarian syndrome and gonadotropin poor-responsiveness, are consequences of dysregulated follicle growth at this transitional stage, understanding the molecular and cellular mechanisms in the control of follicular development during the preantral-early antral transition may provide important insight into the pathophysiology and rational treatment of these conditions.
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影响因子：
3.1
作者：
Craig, Jesse;Orisaka, Makoto;Tsang, Benjamin K.
通讯作者：
Tsang, Benjamin K.
影响因子：
4.8
作者：
Hayashi, M;McGee, EA;Hsueh, AJW
通讯作者：
Hsueh, AJW
影响因子：
3.6
作者：
Huang, CTF;Weitsman, SR;Magoffin, DA
通讯作者：
Magoffin, DA
影响因子：
3.6
作者：
BAGNELL, CA;MILLS, TM;MAHESH, VB
通讯作者：
MAHESH, VB
影响因子：
64.8
作者：
CATTANACH, BM;IDDON, CA;FINK, G
通讯作者：
FINK, G