Effects of bisphenol A on the development, growth, and sex ratio of the housefly Musca domestica
Effects of bisphenol A on the development, growth, and sex ratio of the housefly Musca domestica
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DOI：
10.1897/07-218.1
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发表时间：
2008-06-01
影响因子：
4.1
通讯作者：
Sajiki, Junko
中科院分区：
文献类型：
--
作者：
Izumi, Nanae;Yanagibori, Ryoko;Sajiki, Junko
研究了双酚A（BPA）对家蝇生活史的影响。当卵和幼虫在培养基中暴露于浓度为1，000 μ g kg（-1）的BPA 5代和100 μ g kg（-1）的BPA 7代时，成虫的性别比例有利于雄性。值得注意的是，在100 μ g kg（-1）的初始浓度下，在鸡蛋接种后4小时，生长培养基中的BPA水平下降了61%，24小时后没有检测到BPA。暴露于100 μ g kg（-1）BPA时，蛹的重量增加，但暴露于1，000 μ g kg（-1）BPA后，蛹的重量下降，这表明高度可变的浓度依赖性毒性。卵至3龄幼虫期的存活率和蛹/幼虫的比率均下降，表明BPA对卵和幼虫都有影响。在暴露于>100 μ g kg（-1）BPA的昆虫中，通常观察到羽化时间延迟。与对照组相比，在添加100 μ g/kg BPA的培养基中，第4天和第7天幼虫的保幼激素II和III水平显著升高。这些结果表明，在家蝇生命周期的早期阶段暴露于环境相关浓度的BPA可能会导致各种疾病（蛹重和性别比），这可能是内分泌干扰的结果。
The effects of bisphenol A (BPA) on the life cycle of the housefly Musca domestica were examined. The sex ratio of the imago shifted in favor of males when eggs and larvae were exposed to BPA in culture media at concentrations of 1,000 mu g kg(-1) for five generations and 100 mu g kg(-1) for seven generations. Notably, at an initial concentration of 100 mu g kg(-1), BPA levels in the growth medium decreased 61% at 4 h after egg inoculation, and no BPA was detected after 24 h. Pupal weight increased upon exposure to 100 mu g kg(-1) BPA but decreased after exposure to 1,000 mu g kg(-1), suggesting highly variable concentrationdependent toxicity. Both the survival ratio of eggs to the third instar larval stage and the ratio of pupae to larvae decreased, indicating that BPA affected both eggs and larvae. A delay in the timing of emergence typically was observed in insects exposed to >100 mu g kg(-1) BPA. Compared to the control group, juvenile hormones II and III levels were elevated significantly in larvae between days 4 and 7 in medium spiked with 100 mu g kg(-1) BPA. These results suggest that exposure to environmentally relevant concentrations of BPA during the early stages of the housefly life cycle can result in various disorders (pupal weight and sex ratio) that may be a consequence of endocrine disruption.