Stimulation of the Potassium Transport System in Low Potassium Type Sheep Red Cells by a Specific Antigen Antibody Reaction
Stimulation of the Potassium Transport System in Low Potassium Type Sheep Red Cells by a Specific Antigen Antibody Reaction
复制标题
特异性抗原抗体反应刺激低钾型绵羊红细胞钾转运系统
DOI：
10.1038/222477a0
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发表时间：
1969
期刊：
影响因子：
64.8
通讯作者：
E. M. Tucker
中科院分区：
文献类型：
--
作者：
J. Ellory;E. M. Tucker
一些绵羊的红细胞中钾的浓度很高（HK型），而一些绵羊的红细胞中钾的浓度很低（LK型）1。LK（KaL）基因对HK（kah）基因为显性。Rasmusen和Hall 2，3报道了钾型与成年绵羊红细胞上的抗原（M）之间的关联。除部分LK型红细胞外，所有HK型红细胞均为M阳性，即被抗M同种抗体溶血。他们认为，控制钾浓度的基因也控制M抗原，M（MM）纯合子的绵羊是HK型（kahkah），而M阴性的m（mm）纯合子的绵羊是LK（kaLkaL）基因纯合子。杂合子LK羊（kaLkah）也为M（Mm）杂合子。所有新生羔羊的红细胞含有更多的钾比那些成年HK型羊4，5，并在这些羔羊携带的基因为M，细胞不完全与抗M，直到成年钾浓度reached6，7。结论是，M抗原本身的存在对于维持细胞内高钾含量不是必需的，并且有人建议，如果假设的M因子可以被鉴定，则可能被证明直接参与主动钾转运。这里报告的工作是为了检验这一假设。
SOME sheep have high concentrations of potassium in their red blood cells (HK type) and some have low concentrations (LK type)1. The gene for LK (KaL) is dominant to that for HK (kah). Rasmusen and Hall2,3 reported an association between potassium type and an antigen (M) on the red cells of adult sheep. All HK type but only some LK type red cells were M-positive, that is, they were haemolysed by the isoantibody anti-M. They suggested that genes controlling potassium concentrations also controlled the M antigen, sheep homozygous for M (MM) being HK type (kahkah), and sheep homozygous for m (mm) that is M-negative, being homozygous for the gene for LK (kaLkaL). The heterozygous LK sheep (kaLkah) were also heterozygous for M (Mm). The red cells of all newborn lambs contain more potassium than those of adult HK type sheep4,5, and in those lambs which carry the gene for M, the cells do not react fully with anti-M until adult potassium concentrations are reached6,7. The conclusion was that the presence of M antigen per se was not essential for the maintenance of a high intracellular content of potassium, and it was suggested that if the hypothetical m factor could be identified, it might prove to be directly involved in active potassium transport. The work reported here sets out to test this hypothesis.