Major histocompatibility complex antigen expression of parenchymal cells of thyroid allografts is not by itself sufficient to induce rejection.
Major histocompatibility complex antigen expression of parenchymal cells of thyroid allografts is not by itself sufficient to induce rejection.
复制标题
甲状腺同种异体移植物的实质细胞的主要组织相容性复合物抗原表达本身不足以诱导排斥。
DOI：
10.1097/00007890-199003000-00024
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发表时间：
1990
期刊：
影响因子：
6.2
通讯作者：
Talmage,DW
中科院分区：
文献类型：
--
作者：
LaRosa,FG;Talmage,DW
H-2 d甲状腺在正常大气压下在氧气中培养（次优培养），移植到H-2 B小鼠体内。这些组织中的一些培养与重组小鼠γ-干扰素（rIFN），他们表达高水平的主要组织相容性复合物抗原移植前。三周后，与未诱导的组织相比，观察到MHC诱导的移植物的排斥率无差异（每组50%）。新鲜的（未培养的）移植物在不到2周的时间内被一致排斥。此外，H-2 d甲状腺，免费的捐助者白细胞的预培养在高压氧和超过1年的停车在正常H-2 B收件人，孵育和无rIFN，然后移植到正常H-2 B小鼠; 100%的接受观察到在两组中，无论表达的同种MHC分子的甲状腺细胞。
H-2 d thyroids cultured in oxygen at normal atmospheric pressure (suboptimal culture) were grafted into H-2 b mice. Some of these tissues were cultured with recombinant mouse gamma-interferon (rIFN), and they expressed high levels of major histocompatibility complex antigens before grafting. Three weeks later, no difference in the rate of rejection of MHC-induced grafts was observed as compared with uninduced tissues (50% of each group). Fresh (uncultured) grafts were uniformly rejected in less than 2 weeks. Also, H-2 d thyroids, freed of donor leukocytes by preculture in hyperbaric oxygen and more than 1 year parking in normal H-2 b recipients, were incubated with and without rIFN, and then grafted into normal H-2 b mice; 100% acceptance was observed in both groups regardless of the expression of allo-MHC molecules on thyroid cells.