EFFECTS OF RENAL TRANSPLANTATION ON UREMIC NEUROPATHY - CLINICAL AND ELECTROPHYSIOLOGIC STUDY
EFFECTS OF RENAL TRANSPLANTATION ON UREMIC NEUROPATHY - CLINICAL AND ELECTROPHYSIOLOGIC STUDY
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DOI：
10.1056/nejm197105272842102
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发表时间：
1971-01-01
影响因子：
158.5
通讯作者：
BALTZAN, RB
中科院分区：
文献类型：
--
作者：
BOLTON, CF;BALTZAN, MA;BALTZAN, RB
10例尿毒症性神经病变患者中有3例在肾移植成功后2个月开始改善，功能在1年内完全恢复，但仍有残留的临床体征和电生理异常。在两名中重度多发性神经病患者中，一名在8个月内恢复，但一名老年患者在一年后仅部分恢复。其余5例为亚临床;其中3例神经传导速度在4 ~ 6个月内恢复正常。压迫性单神经病，一个额外的并发症，在两名患者，也得到改善。电生理研究表明，节段性髓鞘再生和神经轴突再生都是修复过程的一部分。
In three of 10 patients with uremic neuropathy improvement began two months after successful renal transplantation, and functional recovery was complete in a year, although residual clinical signs and electrophysiologic abnormalities remained. Of two patients with moderately severe polyneuropathy, one recovered in eight months, but an older patient had only partial recovery after a year. The remaining five cases were subclinical; in three of these, nerve-conduction velocities returned to normal in four to six months. Compressive mononeuropathy, an additional complication in two patients, also improved. Electrophysiologic studies suggest that segmental remyelination and nerve axon regeneration are both a part of the reparative process.