Solid‐State C-N Cross‐Coupling Reactions with Carbazoles as Nitrogen Nucleophiles Using Mechanochemistry
Solid‐State C-N Cross‐Coupling Reactions with Carbazoles as Nitrogen Nucleophiles Using Mechanochemistry
复制标题
使用机械化学与咔唑作为氮亲核试剂进行固态 C-N 交叉偶联反应
DOI：
10.1002/cssc.202102132
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发表时间：
2021
期刊：
影响因子：
8.4
通讯作者：
Ito Hajime
中科院分区：
文献类型：
--
作者：
Kubota Koji;Endo Tsubura;Uesugi Minami;Hayashi Yuta;Ito Hajime
已经报道了经由高温球磨技术的钯催化的咔唑与芳基卤化物的固态C-N交叉偶联。该反应允许简单，快速，高效地合成N-芳基咔唑衍生物，产率良好，无需在空气中使用大量有机溶剂。重要的是，开发的固态偶联方法使难溶性芳基卤化物与在常规溶液条件下几乎不反应的大聚芳族结构发生交叉偶联。
The palladium‐catalyzed solid‐state C−N cross‐coupling of carbazoles with aryl halides via a high‐temperature ball‐milling technique has been reported. This reaction allowed simple, fast, and efficient synthesis ofN‐arylcarbazole derivatives in good to excellent yields without the use of large amounts of organic solvents in air. Importantly, the developed solid‐state coupling approach enabled the cross‐coupling of poorly soluble aryl halides with large polyaromatic structures that are barely reactive under conventional solution‐based conditions.