The effects of almond consumption on fasting blood lipid levels: a systematic review and meta-analysis of randomised controlled trials.
The effects of almond consumption on fasting blood lipid levels: a systematic review and meta-analysis of randomised controlled trials.
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DOI：
10.1017/jns.2016.19
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发表时间：
2016
影响因子：
2.5
通讯作者：
Lee, Han Youl
中科院分区：
文献类型：
--
作者：
Musa-Veloso, Kathy;Paulionis, Lina;Poon, Theresa;Lee, Han Youl
对随机对照试验进行了系统回顾和荟萃分析，以确定杏仁消费对血脂水平的影响，即总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C），TAG以及TC：HDL-C和LDL-C：HDL-C的比值。在对科学文献进行全面检索后，共确定了18篇相关出版物和27个杏仁对照数据集。在所有研究中，使用随机效应模型在荟萃分析中汇总每个血脂参数（即对照校正值）的效应平均差异。经测定，TC、LDL-C和TAG分别显著降低了−0·153 mmol/l（P < 0·001）、−0·124 mmol/l（P = 0·001）和−0·067 mmol/l（P = 0·042），HDL-C未受影响（−0·017 mmol/l; P = 0·207）。这些结果与前瞻性观察性研究和最近的一项大规模干预研究的数据一致，该研究表明食用坚果可以降低心脏病的风险。应鼓励食用坚果作为健康饮食的一部分，以帮助维持健康的血脂水平，并降低患心脏病的风险。
A systematic review and meta-analysis of randomised controlled trials was undertaken to determine the effects of almond consumption on blood lipid levels, namely total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG and the ratios of TC:HDL-C and LDL-C:HDL-C. Following a comprehensive search of the scientific literature, a total of eighteen relevant publications and twenty-seven almond-control datasets were identified. Across the studies, the mean differences in the effect for each blood lipid parameter (i.e. the control-adjusted values) were pooled in a meta-analysis using a random-effects model. It was determined that TC, LDL-C and TAG were significantly reduced by −0·153 mmol/l (P < 0·001), −0·124 mmol/l (P = 0·001) and −0·067 mmol/l (P = 0·042), respectively, and that HDL-C was not affected (−0·017 mmol/l; P = 0·207). These results are aligned with data from prospective observational studies and a recent large-scale intervention study in which it was demonstrated that the consumption of nuts reduces the risk of heart disease. The consumption of nuts as part of a healthy diet should be encouraged to help in the maintenance of healthy blood lipid levels and to reduce the risk of heart disease.