Desikan-Killiany-Tourville Atlas Compatible Version of M-CRIB Neonatal Parcellated Whole Brain Atlas: The M-CRIB 2.0
Desikan-Killiany-Tourville Atlas Compatible Version of M-CRIB Neonatal Parcellated Whole Brain Atlas: The M-CRIB 2.0
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DOI：
10.3389/fnins.2019.00034
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发表时间：
2019-02-05
影响因子：
4.3
通讯作者：
Thompson, Deanne K.
中科院分区：
文献类型：
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作者：
Alexander, Bonnie;Loh, Wai Yen;Thompson, Deanne K.
我们最近发表的M-CRIB图谱包括100个新生儿大脑区域，其中68个与广泛使用的Desikan-Killiany成人皮质图谱兼容。Desikan-Killiany地图集的后继者是Desikan-Killiany-Tourville地图集，其中删除了一些边界不清晰的区域，并修改了许多现有的边界，以符合沟底更清晰的地标。我们的第一个目标是修改皮质M-CRI B区域，使其符合Desikan-Killiany-Tourville协议，以便提供：（a）与该成人皮质图谱的兼容性，（B）由于更清晰的标志而具有更高的标记准确性，以及（0）优化皮质区域，以便与基于表面的婴儿包裹管道集成。其次，我们的目标是更新皮层下区域，以便与FreeSurfer中产生的皮层下分割提供更大的兼容性。使用的数据是我们的M-CRIB图谱中的T2加权MRI扫描，针对10名健康新生儿（MRI时月经后年龄为40-43周，4名女性），以及相应的分组图像。使用ITK-SNAP对体积空间中的包裹图像进行编辑。皮质更新包括删除额叶和颞极和“银行STS”，以及修改许多其他地区的边界。皮质下区域的变化包括增加“腹侧间脑”和删除“皮质下物质”标签。制定了详细的最新包裹方案。由此产生的全脑M-CRIB 2.0图谱总共包括94个区域。该图谱提供了与成人Desikan-Killiany-Tourville标记的皮质数据和FreeSurfer标记的皮质下数据的可比性，并且更容易适用于纳入基于表面的新生儿包裹管道。因此，它提供了帮助促进对新生儿时间点和整个生命周期发育的大脑结构和功能进行广泛调查的能力。
Our recently published M-CRIB atlas comprises 100 neonatal brain regions including 68 compatible with the widely-used Desikan-Killiany adult cortical atlas. A successor to the Desikan-Killiany atlas is the Desikan-Killiany-Tourville atlas, in which some regions with unclear boundaries were removed, and many existing boundaries were revised to conform to clearer landmarks in sulcal fundi. Our first aim here was to modify cortical M-CRIB regions to comply with the Desikan-Killiany-Tourville protocol, in order to offer: (a) compatibility with this adult cortical atlas, (b) greater labeling accuracy due to clearer landmarks, and (0) optimisation of cortical regions for integration with surface-based infant parcellation pipelines. Secondly, we aimed to update subcortical regions in order to offer greater compatibility with subcortical segmentations produced in FreeSurfer. Data utilized were the T2-weighted MRI scans in our M-CRIB atlas, for 10 healthy neonates (post-menstrual age at MRI 40-43 weeks, four female), and corresponding parcellated images. Edits were performed on the parcellated images in volume space using ITK-SNAP. Cortical updates included deletion of frontal and temporal poles and 'Banks STS,' and modification of boundaries of many other regions. Changes to subcortical regions included the addition of 'ventral diencephalon,' and deletion of 'subcortical matter' labels. A detailed updated parcellation protocol was produced. The resulting whole-brain M-CRIB 2.0 atlas comprises 94 regions altogether. This atlas provides comparability with adult Desikan-Killiany-Tourville-labeled cortical data and FreeSurfer-labeed subcortical data, and is more readily adaptable for incorporation into surface-based neonatal parcellation pipelines. As such, it offers the ability to help facilitate a broad range of investigations into brain structure and function both at the neonatal time point and developmentally across the lifespan.