The involvement of immunoglobulin superfamily proteins in spermatogenesis and sperm-egg interaction
The involvement of immunoglobulin superfamily proteins in spermatogenesis and sperm-egg interaction
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DOI：
10.1111/j.1447-0578.2006.00129.x
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发表时间：
2006-06
影响因子：
3.4
通讯作者：
K. Toshimori;M. Maekawa;C. Ito;Y. Toyama;F. Suzuki-Toyota;Dinesh k. Saxena
中科院分区：
文献类型：
--
作者：
K. Toshimori;M. Maekawa;C. Ito;Y. Toyama;F. Suzuki-Toyota;Dinesh k. Saxena
免疫球蛋白超家族（IgSF）蛋白质在睾丸中的支持细胞和生殖细胞之间的质膜上表达。IgSF蛋白特异性地存在于顶端支持细胞-生殖细胞连接处，即外质特化，并且参与生殖细胞分化。一些IgSF蛋白存在于生殖细胞的表面，并在精子成熟过程中进行进一步的生化修饰。这些IgSF蛋白在获能和/或顶体反应期间经历最终修饰。IgSF蛋白在睾丸和精子中的功能和表达，因为它们与精子发生和精卵相互作用有关，进行了讨论。
The immunoglobulin superfamily (IgSF) proteins are expressed on the plasma membrane between Sertoli cells and germ cells in the testis. IgSF proteins are specifically present at the apical Sertoli-germ cell junction, that is, ectoplasmic specialization and are involved in germ cell differentiation. Some IgSF proteins are present on the surface of germ cells and undergo further biochemical modifications during sperm maturation. These IgSF proteins undergo final modifications during capacitation and/or the acrosome reaction. The function and expression of IgSF proteins in the testis and spermatozoa, as they relate to spermatogenesis and sperm-egg interaction, are discussed.